GABARAPL1 and TBC1D2

Number of citations of the paper that reports this interaction (PubMedID 22354992)
55

Data Source:
BioGRID (affinity chromatography technology, pull down)

		GABARAPL1	TBC1D2
Description		GABA type A receptor associated protein like 1	TBC1 domain family member 2
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GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Mitochondrion Autophagosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Ciliary Basal Body	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Junction Cytoplasmic Vesicle Anchoring Junction
	Molecular Function	Protein Binding Phospholipid Binding Phosphatidylethanolamine Binding Tat Protein Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding	GTPase Activator Activity Protein Binding Cadherin Binding
	Biological Process	Autophagosome Assembly Mitophagy Autophagy Cellular Response To Nitrogen Starvation Glycophagy Autophagosome Maturation	Positive Regulation Of GTPase Activity Regulation Of Cilium Assembly
Pathways		Macroautophagy	TBC/RABGAPs
Drugs
Diseases
GWAS			Femur bone mineral density x serum urate levels interaction ( 34046847) Metabolite levels ( 23823483) Post-traumatic stress disorder ( 26114229) Rate of ventricular enlargement ( 31711042) Severe influenza A (H1N1) infection ( 26379185)
Interacting Genes		87 interacting genes: AHNAK2 AMBRA1 ANK2 APPL1 ARFGAP1 ATG13 ATG4A ATG4B ATG4D AZI2 BICC1 BNIP3L BRD9 BSCL2 BSDC1 CALCOCO1 CALCOCO2 CARS2 CCT2 CDC37 CREB3L2 CUL3 DISC1 DVL2 DYNLL1 ERBB2 ERBB3 FUNDC1 G3BP1 KBTBD7 KRTAP10-3 KRTAP10-7 KRTAP10-9 KXD1 MAP4K2 MAPK15 MEFV MLX MYBPC1 NCOR1 NEDD4 NFIA NUFIP2 OPRK1 OPTN OSBPL3 PBXIP1 PSMB4 PTPRR RABGAP1 RABGAP1L RB1CC1 RCN2 RESF1 RETREG3 SCYL3 SEC62 SNCA SQSTM1 SRPK1 SRPK2 STK3 STRN3 TAX1BP1 TBC1D1 TBC1D10A TBC1D10B TBC1D16 TBC1D17 TBC1D2 TBC1D25 TBC1D2B TBC1D5 TBC1D7 TBC1D9 TBC1D9B THAP7 TMEM131 TNIP1 TP53INP1 TRIM21 TRIM25 TRIM32 UMAD1 VDR WDFY3 ZBTB22	10 interacting genes: AURKA BUB1 CCND1 DCC GABARAPL1 KCTD6 MAP1LC3A MLH3 PDGFRL UBC
Entrez ID		23710	55357
HPRD ID		07601	11624
Ensembl ID		ENSG00000139112	ENSG00000095383
Uniprot IDs		Q9H0R8	Q9BYX2
PDB IDs		2L8J 2R2Q 5DPT 5LXH 5LXI 6HOI 6HOL 6YOO 7AA7 7AA9 7JHX 8X8A	2DHK
Enriched GO Terms of Interacting Partners?		Autophagosome Regulation Of Cilium Assembly Autophagy Macroautophagy GTPase Activator Activity Regulation Of Organelle Assembly Cytosol Regulation Of Autophagy Positive Regulation Of Autophagy Autophagy Of Mitochondrion Regulation Of Cell Projection Assembly Mitophagy Autophagosome Assembly Autophagosome Organization Aggrephagy Cytoplasmic Vesicle Piecemeal Microautophagy Of The Nucleus Cytoplasm Regulation Of Cell Projection Organization Microautophagy Nucleophagy Positive Regulation Of Catabolic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Vacuole Organization Regulation Of Organelle Organization Positive Regulation Of Metabolic Process Protein-phosphatidylethanolamide Deconjugating Activity Catabolic Process Protein Delipidation Response To Mitochondrial Depolarisation Organelle Assembly Regulation Of Macroautophagy Atg1/ULK1 Kinase Complex Regulation Of Cellular Component Organization Positive Regulation Of Macroautophagy Regulation Of Intracellular Signal Transduction Protein Polyubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Phagophore Assembly Site Negative Regulation Of Signal Transduction ERBB3:ERBB2 Complex Protein Localization To Phagocytic Vesicle Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Metabolic Process Response To Stress Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Viral Process	Ubiquitin Protein Ligase Binding Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Liver Regeneration Response To Iron Ion Positive Regulation Of Cell Cycle Process Animal Organ Regeneration Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity Mitophagy Autophagosome Maturation Autophagosome Membrane Regulation Of Mitotic Cell Cycle Phase Transition Cyclin D1-CDK4 Complex Cyclin D1-CDK6 Complex Positive Regulation Of Cell Cycle Platelet-derived Growth Factor Beta-receptor Activity Platelet-derived Growth Factor Receptor Activity Microtubule Autophagy Of Mitochondrion Autophagosome Chiasma Microtubule Organizing Center Response To Nutrient Levels Re-entry Into Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Cell Division Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Liver Development Cytosol Regulation Of Mitotic Nuclear Division Meiotic Sister Chromatid Cohesion, Centromeric Dorsal/ventral Axon Guidance Spinal Cord Ventral Commissure Morphogenesis Platelet Activating Factor Receptor Activity Macromolecule Catabolic Process Spindle Assembly Involved In Female Meiosis I Germinal Vesicle Histone H3S10 Kinase Activity Positive Regulation Of Oocyte Maturation Autophagosome Organization Phospholipid Binding Autophagosome Assembly Satellite DNA Binding Cellular Response To Oxygen-glucose Deprivation Positive Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Protein Kinase Activity Regeneration
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