PRR5 and WNT7B

		PRR5	WNT7B
Description		proline rich 5	Wnt family member 7B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol TORC2 Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Endocytic Vesicle Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Signaling Receptor Binding Frizzled Binding Cytokine Activity Protein Binding Receptor Ligand Activity
	Biological Process	Cytoskeleton Organization Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels TORC2 Signaling Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	In Utero Embryonic Development Metanephros Morphogenesis Tissue Development Wnt Signaling Pathway Establishment Or Maintenance Of Polarity Of Embryonic Epithelium Forebrain Regionalization Central Nervous System Vasculogenesis Cell Differentiation Neuron Differentiation Lung Development Neuron Projection Development Intracellular Oxygen Homeostasis Regulation Of Cell Projection Size Chemoattraction Of Dopaminergic Neuron Axon Homeostatic Process Cell Fate Commitment Positive Regulation Of Osteoblast Differentiation Positive Regulation Of JNK Cascade Fibroblast Proliferation Animal Organ Development Embryonic Organ Development System Development Neuron Projection Morphogenesis Synapse Organization Response To Glucocorticoid Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Lung Morphogenesis Lung Epithelium Development Lobar Bronchus Development Trachea Cartilage Morphogenesis Developmental Growth Involved In Morphogenesis Embryonic Placenta Morphogenesis Chorio-allantoic Fusion Mammary Gland Epithelium Development Lens Fiber Cell Development Cellular Response To Retinoic Acid Renal Inner Medulla Development Renal Outer Medulla Development Outer Medullary Collecting Duct Development Inner Medullary Collecting Duct Development Stem Cell Proliferation Metanephric Collecting Duct Development Metanephric Epithelium Development Metanephric Loop Of Henle Development
Pathways		PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Binge eating behaviour in bipolar disorder ( 24882193 29391396) Electroencephalographic traits in alcoholism ( 22554406)	Appendicular lean mass ( 33097823) Body mass index ( 25760438) Central corneal thickness ( 28171582 29847655) Corneal curvature ( 25823570) Dupuytren's disease ( 28886342 21732829) Heel bone mineral density ( 30598549) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Macular thickness ( 30535121) Optic disc size ( 31809533) Pancreas volume ( 34128465) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278) Rosacea symptom severity ( 29771307) Type 2 diabetes ( 32499647)
Interacting Genes		8 interacting genes: CTNNA3 DESI1 GPSM3 HGS SCUBE1 TTC38 USHBP1 WNT7B	6 interacting genes: CASK CUL3 ELOC GPC3 PORCN PRR5
Entrez ID		55615	7477
HPRD ID		18696	03573
Ensembl ID		ENSG00000186654	ENSG00000188064
Uniprot IDs		P85299	A8K0G1 P56706
PDB IDs
Enriched GO Terms of Interacting Partners?		Chemoattraction Of Dopaminergic Neuron Axon Establishment Or Maintenance Of Polarity Of Embryonic Epithelium Lobar Bronchus Development Trachea Cartilage Morphogenesis Renal Outer Medulla Development Outer Medullary Collecting Duct Development Bronchus Development Chemoattraction Of Axon Metanephric Loop Of Henle Development Inner Medullary Collecting Duct Development Renal Inner Medulla Development ESCRT-0 Complex	Wnt Signaling Pathway Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Peptidyl-dipeptidase Inhibitor Activity Trophectodermal Cellular Morphogenesis Liver Morphogenesis Wnt Protein Secretion Palmitoleoyltransferase Activity Protein Palmitoleylation
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