OTUB1 and OTUD6B

Number of citations of the paper that reports this interaction (PubMedID 22939629)
52

Data Source:
BioGRID (biochemical, affinity chromatography technology, pull down, affinity chromatography technology, biochemical)

		OTUB1	OTUD6B
Description		OTU deubiquitinase, ubiquitin aldehyde binding 1	OTU deubiquitinase 6B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Extracellular Exosome	Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeNEDDylase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin-protein Transferase Inhibitor Activity	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Adaptive Immune Response Immune System Process DNA Repair Proteolysis DNA Damage Response Protein Deubiquitination Cellular Response To Nutrient Levels TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Double-strand Break Repair	Proteolysis Cell Population Proliferation Protein Deubiquitination Negative Regulation Of Translation Proteasome Assembly Positive Regulation Of Translation
Pathways		Ub-specific processing proteases Ovarian tumor domain proteases
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756)
Interacting Genes		60 interacting genes: ACVR1 ACVR1B ANXA1 ANXA7 AURKA BIRC2 BMPR1A BMPR1B CCN6 CD274 CDKN1A CEBPA CPEB2 CSNK2A1 ECT2 ESR1 H2AX HSF1 IL1RL2 KDM1A LINC00857 MAPT MSH2 MYC NEDD8 OTUD6B PACS1 PJA1 RFFL RHOA RNF126 RNF128 SETD7 SMAD2 SMAD3 SMAD4 SMAD9 SNAI1 TGFBR1 TP53 TRAF6 TRIM54 TRIM55 TRIM63 TSC22D1 TTR UBA6 UBC UBD UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2S UBE2Z UBE4B USP15 USP21 USP28 YAP1	6 interacting genes: LIN28B NEDD8 OTUB1 SMURF1 UBC VHL
Entrez ID		55611	51633
HPRD ID		08493	13041
Ensembl ID		ENSG00000167770	ENSG00000155100
Uniprot IDs		B3KUV5 Q96FW1	A0A087X0W9 Q8N6M0
PDB IDs		2ZFY 3VON 4DDG 4DDI 4DHZ 4I6L 4LDT
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Regulation Of Programmed Cell Death Protein Ubiquitination Regulation Of Apoptotic Process Protein Metabolic Process Protein Modification By Small Protein Conjugation Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process SMAD Binding Modification-dependent Protein Catabolic Process I-SMAD Binding Regulation Of Cell Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Developmental Process In Utero Embryonic Development Negative Regulation Of Apoptotic Process Ubiquitin-dependent Protein Catabolic Process Chordate Embryonic Development Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Programmed Cell Death Proteolysis Involved In Protein Catabolic Process Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Response To Stress Protein Polyubiquitination Proteolysis Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Activity Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transforming Growth Factor Beta Receptor Activity, Type I Activin Receptor Signaling Pathway Response To Growth Factor Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Macromolecule Catabolic Process Regulation Of Gene Expression Regulation Of Developmental Process Ubiquitin Conjugating Enzyme Activity Response To Ionizing Radiation Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Macromolecule Biosynthetic Process	Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Catabolic Process Proteolysis Protein Tag Activity Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Modification Process Ubiquitin Protein Ligase Binding Nucleoplasm Negative Regulation Of TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Engulfment Of Target By Autophagosome Negative Regulation Of TOR Signaling Proteasomal Protein Catabolic Process Macromolecule Metabolic Process Regulation Of TORC1 Signaling Protein Metabolic Process Protein Catabolic Process Cytosol Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Pre-miRNA Processing Regulation Of TOR Signaling Cellular Response To Camptothecin Ubiquitin-protein Transferase Inhibitor Activity DeNEDDylase Activity Activin Receptor Binding Positive Regulation Of MiRNA Catabolic Process Extracellular Exosome Transcription Elongation Factor Activity Substrate Localization To Autophagosome Negative Regulation Of MiRNA Processing Ubiquitin-protein Transferase Activity MiRNA Catabolic Process Cytoplasm I-SMAD Binding Protein Targeting To Vacuole Involved In Autophagy Ectoderm Development Negative Regulation Of Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Binding Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing Regulation Of MiRNA Processing Pre-miRNA Processing Regulation Of Regulatory NcRNA Processing Receptor Catabolic Process Regulation Of Proteolysis
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