OTUB1 and LINC00857

Number of citations of the paper that reports this interaction (PubMedID 36272615)
0

Data Source:
BioGRID (unspecified method, affinity chromatography technology)

		OTUB1	LINC00857
Description		OTU deubiquitinase, ubiquitin aldehyde binding 1	long intergenic non-protein coding RNA 857
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeNEDDylase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin-protein Transferase Inhibitor Activity
	Biological Process	Adaptive Immune Response Immune System Process DNA Repair Proteolysis DNA Damage Response Protein Deubiquitination Cellular Response To Nutrient Levels TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Double-strand Break Repair
Pathways		Ub-specific processing proteases Ovarian tumor domain proteases
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756)
Interacting Genes		60 interacting genes: ACVR1 ACVR1B ANXA1 ANXA7 AURKA BIRC2 BMPR1A BMPR1B CCN6 CD274 CDKN1A CEBPA CPEB2 CSNK2A1 ECT2 ESR1 H2AX HSF1 IL1RL2 KDM1A LINC00857 MAPT MSH2 MYC NEDD8 OTUD6B PACS1 PJA1 RFFL RHOA RNF126 RNF128 SETD7 SMAD2 SMAD3 SMAD4 SMAD9 SNAI1 TGFBR1 TP53 TRAF6 TRIM54 TRIM55 TRIM63 TSC22D1 TTR UBA6 UBC UBD UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2S UBE2Z UBE4B USP15 USP21 USP28 YAP1	2 interacting genes: FOXM1 OTUB1
Entrez ID		55611	439990
HPRD ID		08493
Ensembl ID		ENSG00000167770	ENSG00000237523
Uniprot IDs		B3KUV5 Q96FW1
PDB IDs		2ZFY 3VON 4DDG 4DDI 4DHZ 4I6L 4LDT
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Regulation Of Programmed Cell Death Protein Ubiquitination Regulation Of Apoptotic Process Protein Metabolic Process Protein Modification By Small Protein Conjugation Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process SMAD Binding Modification-dependent Protein Catabolic Process I-SMAD Binding Regulation Of Cell Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Developmental Process In Utero Embryonic Development Negative Regulation Of Apoptotic Process Ubiquitin-dependent Protein Catabolic Process Chordate Embryonic Development Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Programmed Cell Death Proteolysis Involved In Protein Catabolic Process Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Response To Stress Protein Polyubiquitination Proteolysis Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Activity Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transforming Growth Factor Beta Receptor Activity, Type I Activin Receptor Signaling Pathway Response To Growth Factor Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Macromolecule Catabolic Process Regulation Of Gene Expression Regulation Of Developmental Process Ubiquitin Conjugating Enzyme Activity Response To Ionizing Radiation Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Macromolecule Biosynthetic Process	Regulation Of Double-strand Break Repair Regulation Of DNA Repair Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress DNA Repair Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Stress-activated MAPK Cascade Ubiquitin-protein Transferase Inhibitor Activity DeNEDDylase Activity DNA Metabolic Process DNA Damage Response Negative Regulation Of Intracellular Signal Transduction Protein K48-linked Deubiquitination Negative Regulation Of Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Cycle G2/M Phase Transition DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Cell Communication Regulation Of Ras Protein Signal Transduction G2/M Transition Of Mitotic Cell Cycle Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Signaling Negative Regulation Of DNA Repair Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling TORC1 Signaling Negative Regulation Of Double-strand Break Repair Cellular Response To Stress Positive Regulation Of Double-strand Break Repair Signal Transduction By P53 Class Mediator Intracellular Signal Transduction Positive Regulation Of TOR Signaling Cysteine-type Deubiquitinase Activity Protein Deubiquitination Regulation Of TORC1 Signaling Negative Regulation Of TOR Signaling TOR Signaling Ubiquitin Binding Regulation Of Intracellular Signal Transduction Nucleic Acid Metabolic Process Protein Modification By Small Protein Removal
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