OTUD5 and NEDD8

Number of citations of the paper that reports this interaction (PubMedID 30659753)
0

Data Source:
BioGRID (pull down)

		OTUD5	NEDD8
Description		OTU deubiquitinase 5	NEDD8 ubiquitin like modifier
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GO Annotations	Cellular Component	Nucleus Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K63-linked Deubiquitinase Activity Deubiquitinase Activity K48-linked Deubiquitinase Activity	Protein Binding Protein Tag Activity Ubiquitin Protein Ligase Binding
	Biological Process	Negative Regulation Of Cytokine Production Proteolysis Neural Crest Cell Differentiation Protein Deubiquitination Cell Differentiation Negative Regulation Of Type I Interferon Production Response To Lipopolysaccharide Regulation Of Immune Response Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of TORC1 Signaling Positive Regulation Of TORC2 Signaling	Regulation Of Transcription By RNA Polymerase II Proteolysis Ubiquitin-dependent Protein Catabolic Process Intracellular Protein Localization Anatomical Structure Morphogenesis Protein Ubiquitination Modification-dependent Protein Catabolic Process Regulation Of Proteolysis Protein Modification Process Protein Neddylation Cellular Response To Camptothecin Regulation Of Postsynapse Assembly
Pathways		Ovarian tumor domain proteases Negative regulators of DDX58/IFIH1 signaling	TGF-beta receptor signaling activates SMADs UCH proteinases Cargo recognition for clathrin-mediated endocytosis Neddylation Iron uptake and transport
Drugs
Diseases
GWAS			Mean corpuscular volume ( 29403010) Systolic blood pressure (cigarette smoking interaction) ( 26752167)
Interacting Genes		12 interacting genes: ARPC3 NEDD8 NONO PDCD5 POLR2A POLR2B POLR2C SUB1 TP53 TRAF3 UBC UBR5	72 interacting genes: AHR ANKRD13D ARIH2 ATE1 ATXN3 BAG3 CBLB CDC34 COPS5 COPS6 CTRC CUL1 CUL2 CUL3 CUL4B DNAJA2 DNAJB2 DNMT3B EIF3I FAF1 GARS1 GHR GRN GTF3C3 HDAC6 HGS HIF1A HSPA1B HSPA4 HSPA4L HSPA8 HSPA9 HSPH1 HYPK KLHDC2 N4BP1 NAE1 NSFL1C NUB1 NXPH2 OLFML2B OTUB1 OTUB2 OTUD5 OTUD6B PARP1 PCNA POLI PPP1CA PRKN PSMA6 PSMD4 PTK2 RAD23A SENP8 SET SIRT1 SMURF1 SQSTM1 TOLLIP TP53 TUBB4B UBA2 UBA3 UBE2K UBE2M UBL7 UBQLN1 UBXN7 UCHL1 UCHL3 YAF2
Entrez ID		55593	4738
HPRD ID		06488	04412
Ensembl ID		ENSG00000068308	ENSG00000129559
Uniprot IDs		Q96G74	Q15843
PDB IDs		3PFY 3TMO 3TMP	1NDD 1R4M 1R4N 1XT9 2BKR 2KO3 2N7K 2NVU 3DBH 3DBL 3DBR 3DQV 3GZN 4F8C 4FBJ 4HCP 4P5O 6R7F 6R7I 6TTU 7B5L 7B5N 7ONI 8B3G 8B3I 8CAF 8H38 8Q7H 8RX0 8WQC 8WQG 8WZN 8WZO
Enriched GO Terms of Interacting Partners?		RNA Polymerase II, Core Complex Ubiquitin Protein Ligase Binding RNA-directed RNA Polymerase Activity RNA-templated Transcription DNA-directed RNA Polymerase Activity DNA-directed RNA Polymerase Complex DNA-templated Transcription 5'-3' RNA Polymerase Activity MRNA Transcription RNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Biosynthetic Process Protein Tag Activity Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Nucleus DNA Binding Nucleoplasm Macromolecule Biosynthetic Process RNA Binding MRNA Metabolic Process Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Growth Cone Leading Edge Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Transcription Initiation By RNA Polymerase II Transcription By RNA Polymerase II Interferon-mediated Signaling Pathway Promoter-specific Chromatin Binding Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Heterochromatin Boundary Formation Regulation Of DNA-templated Transcription Initiation Regulation Of Proteolysis Nucleotidyltransferase Activity Ribonucleoside Binding Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Oxidative Stress-induced Premature Senescence Site Of Double-strand Break Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Cellular Response To Actinomycin D Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Regulation Of Circadian Rhythm Positive Regulation Of Thymocyte Apoptotic Process	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Ubiquitin Protein Ligase Binding Proteasomal Protein Catabolic Process Ubiquitin Binding Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Protein Modification Process Protein Modification By Small Protein Conjugation Cytosol Positive Regulation Of Catabolic Process Protein Modification By Small Protein Removal Regulation Of Protein Metabolic Process Nucleoplasm Regulation Of Post-translational Protein Modification Regulation Of Proteolysis Protein Ubiquitination Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Deubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Nucleus Protein Polyubiquitination Protein Targeting To Vacuole Involved In Autophagy Cullin-RING Ubiquitin Ligase Complex DeNEDDylase Activity Aggresome ATP-dependent Protein Folding Chaperone Polyubiquitin Modification-dependent Protein Binding Regulation Of Proteasomal Protein Catabolic Process Protein Folding Response To Stress Protein Neddylation Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Stability Positive Regulation Of Metabolic Process Cellular Response To Stress Cytoplasm
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