ELAC1 and CCDC68

		ELAC1	CCDC68
Description		elaC ribonuclease Z 1	coiled-coil domain containing 68
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytoplasm Centriole Cytoskeleton Centriolar Subdistal Appendage
	Molecular Function	Nuclease Activity Endonuclease Activity TRNA-specific Ribonuclease Activity Hydrolase Activity RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism 3'-tRNA Processing Endoribonuclease Activity Metal Ion Binding	Protein Binding
	Biological Process	TRNA 3'-terminal CCA Addition TRNA Processing TRNA 3'-end Processing Rescue Of Stalled Ribosome	Intracellular Protein Localization Microtubule Anchoring At Centrosome
Pathways
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Oligoclonal band status in multiple sclerosis ( 25616667)	Age-related hearing impairment ( 34108613) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Chin dimples ( 27182965) Depression ( 29700475) Diabetic retinopathy ( 21441570) Diastolic blood pressure ( 30224653) Intraocular pressure ( 29617998) Mean platelet volume ( 32888494) Schizophrenia ( 21926974 30285260) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		4 interacting genes: CCDC68 MIR200C MIR25 PJA1	4 interacting genes: DYNLT1 ELAC1 KRT27 TFIP11
Entrez ID		55520	80323
HPRD ID		16275	18034
Ensembl ID		ENSG00000141642	ENSG00000166510
Uniprot IDs		Q9H777	Q9H2F9
PDB IDs		3ZWF
Enriched GO Terms of Interacting Partners?		MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Mesodermal Cell Differentiation Negative Regulation Of Interleukin-33 Production Regulation Of Muscle System Process Negative Regulation Of Calcium Ion Import Across Plasma Membrane Centriolar Subdistal Appendage Microtubule Anchoring At Centrosome Microtubule Anchoring At Microtubule Organizing Center Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Mesodermal Cell Differentiation Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Endothelial Cell Differentiation Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Microtubule Anchoring Negative Regulation Of Cardiac Muscle Tissue Growth Regulation Of System Process Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Post-transcriptional Regulation Of Gene Expression	Organelle Organization Transport Of Viral Material Towards Nucleus Intracellular Transport Of Viral Protein In Host Cell Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Spliceosomal Complex Disassembly 3'-tRNA Processing Endoribonuclease Activity U2-type Post-mRNA Release Spliceosomal Complex TRNA 3'-terminal CCA Addition TRNA-specific Ribonuclease Activity RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Host Cell Intracellular Transport Of Virus Secretory Vesicle Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Protection From Non-homologous End Joining At Telomere TRNA 3'-end Processing Telomere Maintenance In Response To DNA Damage Cytoplasmic Dynein Complex
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