ELAC1

Description		elaC ribonuclease Z 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nuclease Activity Endonuclease Activity TRNA-specific Ribonuclease Activity Hydrolase Activity RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism 3'-tRNA Processing Endoribonuclease Activity Metal Ion Binding
	Biological Process	TRNA 3'-terminal CCA Addition TRNA Processing TRNA 3'-end Processing Rescue Of Stalled Ribosome
Pathways
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Oligoclonal band status in multiple sclerosis ( 25616667)
Novel Interacting Genes		4 novel interacting genes: CCDC68 MIR200C MIR25 PJA1
Interacting Genes		4 interacting genes: CCDC68 MIR200C MIR25 PJA1
Entrez ID		55520
HPRD ID		16275
Ensembl ID		ENSG00000141642
Uniprot IDs		Q9H777
PDB IDs		3ZWF
Enriched GO Terms of Interacting Partners?		MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Mesodermal Cell Differentiation Negative Regulation Of Interleukin-33 Production Regulation Of Muscle System Process Negative Regulation Of Calcium Ion Import Across Plasma Membrane Centriolar Subdistal Appendage Microtubule Anchoring At Centrosome Microtubule Anchoring At Microtubule Organizing Center Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Mesodermal Cell Differentiation Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Endothelial Cell Differentiation Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Microtubule Anchoring Negative Regulation Of Cardiac Muscle Tissue Growth Regulation Of System Process Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Post-transcriptional Regulation Of Gene Expression
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