KIRREL1 and TJP1

Number of citations of the paper that reports this interaction (PubMedID 12865409)
37

Data Source:
HPRD (in vitro, in vivo)

		KIRREL1	TJP1
Description		kirre like nephrin family adhesion molecule 1	tight junction protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Membrane Dendritic Shaft Perinuclear Region Of Cytoplasm	Podosome Cytoplasm Cytosol Plasma Membrane Adherens Junction Gap Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Cell Junction Protein-containing Complex Cell Projection Apical Junction Complex Apical Part Of Cell Tight Junction Anchoring Junction
	Molecular Function	Protein Binding Myosin Binding Cell Adhesion Molecule Binding	Protein Binding Calmodulin Binding Cadherin Binding Cell Adhesion Molecule Binding
	Biological Process	Glomerular Filtration Positive Regulation Of Actin Filament Polymerization Cell-cell Junction Maintenance Renal Protein Absorption Cell-cell Adhesion	Cell-cell Junction Assembly Positive Regulation Of Cell Population Proliferation Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Actomyosin Structure Organization Adherens Junction Maintenance Maintenance Of Blood-brain Barrier Ameloblast Differentiation Negative Regulation Of Apoptotic Process Cell-cell Junction Organization Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Protein Localization To Adherens Junction Establishment Of Endothelial Intestinal Barrier Cell-cell Adhesion Protein Localization To Cell-cell Junction Regulation Of Cell Junction Assembly Protein Localization To Bicellular Tight Junction Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Blood-brain Barrier Permeability Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Regulation Of Bicellular Tight Junction Assembly
Pathways		Nephrin family interactions Nephrin family interactions	Regulation of gap junction activity Regulation of gap junction activity Signaling by Hippo Apoptotic cleavage of cell adhesion proteins RUNX1 regulates expression of components of tight junctions SARS-CoV-2 targets PDZ proteins in cell-cell junction SARS-CoV-2 targets PDZ proteins in cell-cell junction
Drugs
Diseases
GWAS			Central corneal thickness ( 29760442 30894546 31798171 32528159) Corneal structure ( 23291589) Response to antipsychotic treatment ( 23241943) Spleen volume ( 34128465)
Interacting Genes		3 interacting genes: NPHS1 NPHS2 TJP1	41 interacting genes: ACTA1 ACTN4 AFDN ARVCF CGN CLDN1 CLDN16 CLDN2 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CNKSR2 CTNNA1 CTNNB1 CTTN EGFR F11R GJA1 GJA3 GJA8 GJB3 GJC1 GJD3 GRIN1 GRIN2D HSP90AA1 JAM2 JAM3 KHDRBS1 KIRREL1 PEA15 PTPN14 TJP2 TJP3 TRPC4 TTC3 UBN1 YBX3
Entrez ID		55243	7082
HPRD ID		06306	03002
Ensembl ID		ENSG00000183853	ENSG00000104067
Uniprot IDs		B4DN67 Q96J84	A0A087X0K9 A0A0G2JNH2 A0A7I2V5U5 A9CQZ8 B4DZK4 G3V1L9 G5E9E7 Q07157
PDB IDs			2H2B 2H2C 2H3M 2JWE 2KXR 2KXS 2RCZ 3CYY 3LH5 3SHU 3SHW 3TSV 3TSW 3TSZ 4OEO 4OEP 4Q2Q 4YYX
Enriched GO Terms of Interacting Partners?		Epithelial Cell Development Slit Diaphragm Podocyte Development Cell Periphery Protein Localization To Cell Junction Cell Adhesion Molecule Binding Cell Development Cell-cell Junction Assembly Renal System Development Cell-cell Junction Organization Filtration Diaphragm Assembly Slit Diaphragm Assembly Metanephric Podocyte Development Cell-cell Junction Regulation Of Actin Filament Organization Cell Junction Assembly Gene Expression Positive Regulation Of Blood-brain Barrier Permeability Protein Localization To Adherens Junction Protein Localization To Bicellular Tight Junction Adherens Junction Maintenance Regulation Of Actin Cytoskeleton Organization Ameloblast Differentiation Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Blood-brain Barrier Permeability Actin Filament-based Process Glomerular Basement Membrane Development Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Cell Junction Organization Cell-cell Adhesion Establishment Of Endothelial Intestinal Barrier Regulation Of Cytoskeleton Organization Positive Regulation Of Vascular Permeability Glomerular Filtration Protein Localization To Cell-cell Junction Cell-cell Junction Maintenance Renal Filtration Regulation Of Bicellular Tight Junction Assembly Myosin Binding Gap Junction Cellular Developmental Process Positive Regulation Of Sprouting Angiogenesis Myoblast Fusion Apical Junction Complex Maintenance Of Blood-brain Barrier Protein-containing Complex Negative Regulation Of Stress Fiber Assembly Cell-cell Fusion	Anchoring Junction Bicellular Tight Junction Cell-cell Junction Organization Tight Junction Cell-cell Junction Assembly Cell Junction Organization Cell Junction Assembly Cell-cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell-cell Junction Bicellular Tight Junction Assembly Cell Junction Tight Junction Assembly Maintenance Of Blood-brain Barrier Tight Junction Organization Cell Adhesion Plasma Membrane Apicolateral Plasma Membrane Connexin Complex Gap Junction Channel Activity Structural Molecule Activity Anatomical Structure Homeostasis Tissue Homeostasis Gap Junction Establishment Of Endothelial Intestinal Barrier Establishment Of Endothelial Barrier Endothelial Cell Development Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Gap Junction Assembly Cadherin Binding Cell-cell Contact Zone Lateral Plasma Membrane Cell Development Cellular Component Assembly Multicellular Organismal-level Homeostasis Paracellular Transport System Process Epithelial Cell Development Cell-cell Signaling Identical Protein Binding Intercellular Transport Basolateral Plasma Membrane Signaling Cell Communication Membrane Intercalated Disc Regulation Of Locomotion Homeostatic Process Cell Communication By Electrical Coupling Involved In Cardiac Conduction Developmental Process
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