TJP1 and GJD3

Number of citations of the paper that reports this interaction (PubMedID 12154091)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		TJP1	GJD3
Description		tight junction protein 1	gap junction protein delta 3
Image			No pdb structure
GO Annotations	Cellular Component	Podosome Cytoplasm Cytosol Plasma Membrane Adherens Junction Gap Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Cell Junction Protein-containing Complex Cell Projection Apical Junction Complex Apical Part Of Cell Tight Junction Anchoring Junction	Plasma Membrane Gap Junction Connexin Complex Cell Surface Membrane Anchoring Junction
	Molecular Function	Protein Binding Calmodulin Binding Cadherin Binding Cell Adhesion Molecule Binding	Monoatomic Ion Channel Activity Gap Junction Channel Activity Protein Binding Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling
	Biological Process	Cell-cell Junction Assembly Positive Regulation Of Cell Population Proliferation Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Actomyosin Structure Organization Adherens Junction Maintenance Maintenance Of Blood-brain Barrier Ameloblast Differentiation Negative Regulation Of Apoptotic Process Cell-cell Junction Organization Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Protein Localization To Adherens Junction Establishment Of Endothelial Intestinal Barrier Cell-cell Adhesion Protein Localization To Cell-cell Junction Regulation Of Cell Junction Assembly Protein Localization To Bicellular Tight Junction Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Blood-brain Barrier Permeability Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Regulation Of Bicellular Tight Junction Assembly	Cell Communication Cell-cell Signaling Response To Glucose Negative Regulation Of Heart Rate Gap Junction Assembly Monoatomic Ion Transmembrane Transport Transmembrane Transport AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling Cell Communication Involved In Cardiac Conduction Negative Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Cardiac Conduction
Pathways		Regulation of gap junction activity Regulation of gap junction activity Signaling by Hippo Apoptotic cleavage of cell adhesion proteins RUNX1 regulates expression of components of tight junctions SARS-CoV-2 targets PDZ proteins in cell-cell junction SARS-CoV-2 targets PDZ proteins in cell-cell junction	Gap junction assembly
Drugs
Diseases
GWAS		Central corneal thickness ( 29760442 30894546 31798171 32528159) Corneal structure ( 23291589) Response to antipsychotic treatment ( 23241943) Spleen volume ( 34128465)	Platelet distribution width ( 32888494)
Interacting Genes		41 interacting genes: ACTA1 ACTN4 AFDN ARVCF CGN CLDN1 CLDN16 CLDN2 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CNKSR2 CTNNA1 CTNNB1 CTTN EGFR F11R GJA1 GJA3 GJA8 GJB3 GJC1 GJD3 GRIN1 GRIN2D HSP90AA1 JAM2 JAM3 KHDRBS1 KIRREL1 PEA15 PTPN14 TJP2 TJP3 TRPC4 TTC3 UBN1 YBX3	1 interacting genes: TJP1
Entrez ID		7082	125111
HPRD ID		03002	08461
Ensembl ID		ENSG00000104067	ENSG00000183153
Uniprot IDs		A0A087X0K9 A0A0G2JNH2 A0A7I2V5U5 A9CQZ8 B4DZK4 G3V1L9 G5E9E7 Q07157	Q8N144
PDB IDs		2H2B 2H2C 2H3M 2JWE 2KXR 2KXS 2RCZ 3CYY 3LH5 3SHU 3SHW 3TSV 3TSW 3TSZ 4OEO 4OEP 4Q2Q 4YYX
Enriched GO Terms of Interacting Partners?		Anchoring Junction Bicellular Tight Junction Cell-cell Junction Organization Tight Junction Cell-cell Junction Assembly Cell Junction Organization Cell Junction Assembly Cell-cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell-cell Junction Bicellular Tight Junction Assembly Cell Junction Tight Junction Assembly Maintenance Of Blood-brain Barrier Tight Junction Organization Cell Adhesion Plasma Membrane Apicolateral Plasma Membrane Connexin Complex Gap Junction Channel Activity Structural Molecule Activity Anatomical Structure Homeostasis Tissue Homeostasis Gap Junction Establishment Of Endothelial Intestinal Barrier Establishment Of Endothelial Barrier Endothelial Cell Development Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Gap Junction Assembly Cadherin Binding Cell-cell Contact Zone Lateral Plasma Membrane Cell Development Cellular Component Assembly Multicellular Organismal-level Homeostasis Paracellular Transport System Process Epithelial Cell Development Cell-cell Signaling Identical Protein Binding Intercellular Transport Basolateral Plasma Membrane Signaling Cell Communication Membrane Intercalated Disc Regulation Of Locomotion Homeostatic Process Cell Communication By Electrical Coupling Involved In Cardiac Conduction Developmental Process	Protein Localization To Bicellular Tight Junction Positive Regulation Of Blood-brain Barrier Permeability Adherens Junction Maintenance Ameloblast Differentiation Protein Localization To Adherens Junction Regulation Of Blood-brain Barrier Permeability Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Establishment Of Endothelial Intestinal Barrier Protein Localization To Cell-cell Junction Cell-cell Junction Maintenance Positive Regulation Of Vascular Permeability Regulation Of Bicellular Tight Junction Assembly Apical Junction Complex Negative Regulation Of Actin Filament Bundle Assembly Gap Junction Maintenance Of Blood-brain Barrier Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Stress Fiber Assembly Tight Junction Establishment Of Endothelial Barrier Endothelial Cell Development Podosome Regulation Of Vascular Permeability Cell Junction Maintenance Adherens Junction Organization Regulation Of Sprouting Angiogenesis Cellular Component Maintenance Protein Localization To Cell Junction Apical Part Of Cell Cell Adhesion Molecule Binding Regulation Of Stress Fiber Assembly Actomyosin Structure Organization Cell-cell Junction Assembly Bicellular Tight Junction Epithelial Cell Development Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Cell-cell Junction Organization Positive Regulation Of Vasculature Development Anatomical Structure Homeostasis Adherens Junction Tissue Homeostasis Positive Regulation Of Angiogenesis Calmodulin Binding Cell Junction Basolateral Plasma Membrane Regulation Of Cell Junction Assembly Regulation Of Actin Filament Organization Vascular Process In Circulatory System Cell Junction Assembly
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