MACO1 and LCE3E

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MACO1	LCE3E
Description		macoilin 1	late cornified envelope 3E
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Membrane Axon Rough Endoplasmic Reticulum Membrane Nuclear Membrane Cell Projection Neuron Projection Neuron Projection Terminus Synapse
	Molecular Function	Molecular_function Protein Binding Microtubule Binding	Protein Binding
	Biological Process	Chemotaxis Brain Development Neuronal Signal Transduction	Epidermis Development Keratinization
Pathways		RHOA GTPase cycle RHOC GTPase cycle	Formation of the cornified envelope
Drugs
Diseases
GWAS		LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Common traits (Other) ( 20585627) Inflammatory skin disease ( 25574825) Plantar warts ( 28928442) Psoriasis ( 25854761)
Interacting Genes		26 interacting genes: CRCT1 HOXA1 KRTAP5-2 KRTAP5-7 LCE1A LCE1C LCE1D LCE1E LCE1F LCE2C LCE3A LCE3D LCE3E LCE5A LINGO1 MEI4 MEOX2 NBPF19 NOTCH2NLA NR4A3 POTEB3 SMAD9 SMCP SRPK2 TMEM190 ZNF655	59 interacting genes: ADAMTSL4 ALPP CHIC2 CYSRT1 EFEMP2 GRN GSC2 HOXA1 KPRP KRT31 KRT40 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE2A MACO1 MDFI NBPF19 NOTCH2NLA NXF1 PLSCR2 RGS17 RGS20 SPRY1 SPRY2 SPRY3 TRIM42 VWC2
Entrez ID		55219	353145
HPRD ID		13340	13975
Ensembl ID		ENSG00000204178	ENSG00000185966
Uniprot IDs		Q8N5G2	Q5T5B0
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratinization Epidermis Development Tissue Development Developmental Process	Intermediate Filament Keratin Filament Hair Cycle Cytosol Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Epidermis Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Interstitial Matrix Regulation Of Lens Fiber Cell Differentiation Protein Binding Regulation Of Ras Protein Signal Transduction Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Branch Elongation Of An Epithelium Structural Constituent Of Skin Epidermis Negative Regulation Of Small GTPase Mediated Signal Transduction
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