RIC8B and KLHDC2

Number of citations of the paper that reports this interaction (PubMedID 36805027)
68

Data Source:
BioGRID (unspecified method, unspecified method)

		RIC8B	KLHDC2
Description		RIC8 guanine nucleotide exchange factor B	kelch domain containing 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Cell Cortex	Nucleus Nucleoplasm Nuclear Body Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Nuclear Membrane
	Molecular Function	G-protein Alpha-subunit Binding Guanyl-nucleotide Exchange Factor Activity Protein Folding Chaperone	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Protein Folding G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Smell Regulation Of G Protein-coupled Receptor Signaling Pathway	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway
Pathways
Drugs
Diseases
GWAS		Adiponectin levels ( 31178129) Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Night sleep phenotypes ( 27126917) PR interval ( 32439900) Serum alkaline phosphatase levels ( 33547301 33339817) Severe influenza A (H1N1) infection ( 26379185) Social autistic-like traits ( 24133439) Triglyceride levels ( 32154731 32203549 29083408 28334899) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		5 interacting genes: CKAP4 GNAQ GNAS KLHDC2 LRP1	12 interacting genes: ATL1 EML2 ERO1A EZH2 MIS12 NEDD8 RBX1 RIC8B SELENOK SELENOS STRN4 USP1
Entrez ID		55188	23588
HPRD ID		16452	08824
Ensembl ID		ENSG00000111785	ENSG00000165516
Uniprot IDs		B7WPL0 Q9NVN3	Q9Y2U9
PDB IDs			6DO3 6DO4 6DO5 8EBL 8EBM 8EBN 8PIF 8SGE 8SGF 8SH2 8UXS 9BC9 9BCA 9BCC
Enriched GO Terms of Interacting Partners?		Response To Acidic PH Cellular Response To Acidic PH Guanyl Nucleotide Binding Cellular Response To PH G-protein Beta/gamma-subunit Complex Binding Response To Prostaglandin E Heterotrimeric G-protein Complex Response To PH G Protein Activity Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Mu-type Opioid Receptor Binding Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Endocytosis Lipoprotein Particle Receptor Binding Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Hair Follicle Placode Formation Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Activator Activity Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Adenylate Cyclase Regulator Activity Positive Regulation Of Lysosomal Protein Catabolic Process Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Response To Ketone Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Nuclear Membrane Response To Alcohol D1 Dopamine Receptor Binding Beta-2 Adrenergic Receptor Binding Positive Regulation Of Protein Catabolic Process In The Vacuole Positive Regulation Of Amyloid-beta Clearance Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Amyloid-beta Clearance By Cellular Catabolic Process Amyloid-beta Clearance By Transcytosis Lamellar Body Regulation Of Body Fluid Levels Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Regulation Of Wnt Signaling Pathway GTPase Activity Cellular Response To Glucagon Stimulus Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Regulation Of Endocytosis Regulation Of Lysosomal Protein Catabolic Process	Response To Oxidative Stress Protein Modification Process Hepatocyte Homeostasis Cellular Response To Stress Cellular Response To Oxidative Stress Protein Neddylation Positive Regulation Of Error-prone Translesion Synthesis Cell Redox Homeostasis Response To Endoplasmic Reticulum Stress Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Subcompartment Cellular Response To Chemical Stress
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