PRMT6 and MED28

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		PRMT6	MED28
Description		protein arginine methyltransferase 6	mediator complex subunit 28
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Membrane Mediator Complex Cortical Actin Cytoskeleton Core Mediator Complex
	Molecular Function	Chromatin Binding Protein Binding Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone H4R3 Methyltransferase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Histone H3 Methyltransferase Activity	Actin Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Base-excision Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Regulation Of Mitochondrion Organization Methylation Cellular Response To Stress Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Cellular Senescence Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance RNA Polymerase II Preinitiation Complex Assembly Negative Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		RMTs methylate histone arginines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions
Drugs
Diseases
GWAS		Adult body size ( 32376654) Blood pressure measurement (low sodium intervention) ( 24165912) Intelligence ( 22449649) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Refractive error ( 32231278) Response to SSRI in MDD or openness ( 29559929) Restless legs syndrome ( 29029846) Sex hormone-binding globulin levels ( 22829776) Waist circumference ( 28552196) Weight ( 28552196)
Interacting Genes		90 interacting genes: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GPS2 GRHL3 GSTCD GTPBP2 H2AC18 H2BC21 H3-5 H3C14 H3C15 H4C16 H4C6 HESX1 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LINC02875 LOXL4 MALT1 MED28 METTL27 MLC1 MNDA MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PSMD11 PYCR3 PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WDFY3 ZNF436 ZNF557 ZSCAN9	21 interacting genes: CBY2 CEBPA FYN GRB2 GRPEL1 HSP90AA1 KLHL12 LCK MAGEA11 MED30 MED8 MED9 MIIP NF2 PRMT6 PUF60 RAP1GDS1 SRC SUOX TCP11 USHBP1
Entrez ID		55170	80306
HPRD ID		10505	14381
Ensembl ID		ENSG00000198890	ENSG00000118579
Uniprot IDs		Q96LA8	Q9H204
PDB IDs		4HC4 4QPP 4QQK 4Y2H 4Y30 5E8R 5EGS 5HZM 5WCF 6P7I 6W6D 6WAD 7NR4	7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Nucleus Structural Constituent Of Chromatin Protein Binding Nucleosome Nucleoplasm Chromatin Organization Nucleosome Organization Chromatin Remodeling Chromosome Senescence-associated Heterochromatin Focus	Phospholipase Activator Activity T Cell Costimulation Positive Regulation Of DNA-templated Transcription Initiation Phospholipase Binding Regulation Of DNA-templated Transcription Initiation Core Mediator Complex Ephrin Receptor Binding CD8 Receptor Binding Fc-gamma Receptor Signaling Pathway Mediator Complex Non-membrane Spanning Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation RNA Polymerase II Preinitiation Complex Assembly Regulation Of Protein Localization To Nucleus Fc Receptor Signaling Pathway Positive Regulation Of Transcription Elongation By RNA Polymerase II CD4 Receptor Binding Transcription Preinitiation Complex Assembly Protein-containing Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Cell Activation T Cell Receptor Binding Scaffold Protein Binding Regulation Of Transcription Initiation By RNA Polymerase II Identical Protein Binding Activation Of Immune Response Protein-containing Complex Organization Interleukin-6-mediated Signaling Pathway Phosphatidylinositol 3-kinase Binding Protein Phosphatase Binding Regulation Of Transcription Elongation By RNA Polymerase II Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of T Cell Activation Angiotensin-activated Signaling Pathway Regulation Of DNA-templated Transcription Elongation Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Regulation Of Cell-cell Adhesion Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Leukocyte Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Protein Import Into Mitochondrial Matrix Response To Xenobiotic Stimulus Disordered Domain Specific Binding
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