MED28 and GRPEL1

		MED28	GRPEL1
Description		mediator complex subunit 28	GrpE like 1, mitochondrial
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Membrane Mediator Complex Cortical Actin Cytoskeleton Core Mediator Complex	PAM Complex, Tim23 Associated Import Motor Nucleoplasm Mitochondrion Mitochondrial Inner Membrane TIM23 Mitochondrial Import Inner Membrane Translocase Complex Mitochondrial Matrix
	Molecular Function	Actin Binding Protein Binding	Adenyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Unfolded Protein Binding Protein-folding Chaperone Binding
	Biological Process	Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance RNA Polymerase II Preinitiation Complex Assembly Negative Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Transcription Initiation By RNA Polymerase II	Protein Folding Intracellular Protein Transport Protein Import Into Mitochondrial Matrix
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions	Mitochondrial protein import
Drugs
Diseases
GWAS			Eosinophil percentage of white cells ( 32888494)
Interacting Genes		21 interacting genes: CBY2 CEBPA FYN GRB2 GRPEL1 HSP90AA1 KLHL12 LCK MAGEA11 MED30 MED8 MED9 MIIP NF2 PRMT6 PUF60 RAP1GDS1 SRC SUOX TCP11 USHBP1	14 interacting genes: CCDC57 DSP ERCC6 FAM184B FGFBP2 GALT ISG15 MED28 NKX3-2 POLR1C SFTPB SPG21 WBP2 XYLB
Entrez ID		80306	80273
HPRD ID		14381	07550
Ensembl ID		ENSG00000118579	ENSG00000109519
Uniprot IDs		Q9H204	Q9HAV7
PDB IDs		7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH	9BLS 9BLT 9BLU
Enriched GO Terms of Interacting Partners?		Phospholipase Activator Activity T Cell Costimulation Positive Regulation Of DNA-templated Transcription Initiation Phospholipase Binding Regulation Of DNA-templated Transcription Initiation Core Mediator Complex Ephrin Receptor Binding CD8 Receptor Binding Fc-gamma Receptor Signaling Pathway Mediator Complex Non-membrane Spanning Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation RNA Polymerase II Preinitiation Complex Assembly Regulation Of Protein Localization To Nucleus Fc Receptor Signaling Pathway Positive Regulation Of Transcription Elongation By RNA Polymerase II CD4 Receptor Binding Transcription Preinitiation Complex Assembly Protein-containing Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Cell Activation T Cell Receptor Binding Scaffold Protein Binding Regulation Of Transcription Initiation By RNA Polymerase II Identical Protein Binding Activation Of Immune Response Protein-containing Complex Organization Interleukin-6-mediated Signaling Pathway Phosphatidylinositol 3-kinase Binding Protein Phosphatase Binding Regulation Of Transcription Elongation By RNA Polymerase II Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of T Cell Activation Angiotensin-activated Signaling Pathway Regulation Of DNA-templated Transcription Elongation Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Regulation Of Cell-cell Adhesion Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Leukocyte Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Protein Import Into Mitochondrial Matrix Response To Xenobiotic Stimulus Disordered Domain Specific Binding
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