PPP1R7 and CLNK

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		PPP1R7	CLNK
Description		protein phosphatase 1 regulatory subunit 7	cytokine dependent hematopoietic cell linker
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Chromosome Cytoplasm Extracellular Exosome	Cytoplasm Protein-containing Complex Mast Cell Granule
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Enzyme Regulator Activity	Protein Binding Protein-containing Complex Binding
	Biological Process		Positive Regulation Of Natural Killer Cell Cytokine Production Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Natural Killer Cell Activation Intracellular Signal Transduction Mast Cell Degranulation
Pathways
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Family history of Alzheimer's disease ( 30617256) Gout ( 33832965) Resistance to antihypertensive treatment in hypertension ( 28222112) Rheumatoid arthritis ( 24390342 30423114) Systemic lupus erythematosus ( 28714469 33536424) Takayasu arteritis ( 25604533) Urate levels ( 31578528) Uterine fibroid size (maximum dimension) ( 30196971) Vitiligo ( 22561518)
Interacting Genes		16 interacting genes: CLNK FER HGS MAPK6 MYH3 OGT PPP1CB PPP1CC PPP1R3A SPRED1 TAB1 TNFRSF6B UBC UBXN2B USHBP1 VCP	30 interacting genes: ANKRD50 ARAP3 BMX COQ9 CRK CYB561D2 EGFR ERBB2 FAM217A GLIS3 GRB2 GSTCD JAKMIP1 LCP2 NME4 P4HA2 PACSIN3 PIK3R1 PIK3R3 PPP1R7 PTK7 RASSF1 RB1 RPAIN SFMBT1 SMARCD1 SOCS6 STK36 TXK WWOX
Entrez ID		5510	116449
HPRD ID		04192	14720
Ensembl ID		ENSG00000115685	ENSG00000109684
Uniprot IDs		A0A140VK83 Q15435	Q7Z7G1
PDB IDs		6HKW 6MKY 6OBN 6OBP 8B5R 8U5G
Enriched GO Terms of Interacting Partners?		Protein Phosphatase 1 Binding Protein-containing Complex Myosin Phosphatase Activity Glycogen Metabolic Process PTW/PP1 Phosphatase Complex Circadian Regulation Of Gene Expression Energy Reserve Metabolic Process Polysaccharide Metabolic Process Protein Serine/threonine Phosphatase Activity Intracellular Signal Transduction Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Protein-containing Complex Binding Regulation Of Generation Of Precursor Metabolites And Energy Ubiquitin-like Protein Ligase Binding Photoperiodism Entrainment Of Circadian Clock Protein Modification Process Protein Exit From Endoplasmic Reticulum Cytosol Macroautophagy Protein Kinase Binding Energy Derivation By Oxidation Of Organic Compounds Endosome Transport Via Multivesicular Body Sorting Pathway Adherens Junction Disassembly Intracellular Signaling Cassette Myosin-light-chain-phosphatase Activity Flavin Adenine Dinucleotide Catabolic Process Multivesicular Body Sorting Pathway Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Phosphate-containing Compound Metabolic Process Protein Domain Specific Binding Cytoplasm MAPK Cascade Protein Localization To Lysosome Canonical NF-kappaB Signal Transduction Regulation Of Phosphorus Metabolic Process Cell-cell Junction Disassembly Rhythmic Process Septin Cytoskeleton VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination Negative Regulation Of Protein Localization To Centrosome Regulation Of Protein Modification Process Kit Signaling Pathway Protein Metabolic Process Phosphatase Activity Regulation Of ATP Metabolic Process	Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Kinase Binding ErbB-3 Class Receptor Binding Neurotrophin TRKA Receptor Binding 1-phosphatidylinositol-3-kinase Regulator Activity Protein Tyrosine Kinase Activity ERBB2-EGFR Signaling Pathway Phosphatidylinositol 3-kinase Complex Enzyme-linked Receptor Protein Signaling Pathway Phosphatidylinositol 3-kinase Complex, Class IA Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Activity Regulation Of Immune System Process Insulin Receptor Substrate Binding Regulation Of Cell Cycle G1/S Phase Transition Insulin-like Growth Factor Receptor Binding ERBB Signaling Pathway Insulin Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Ras Protein Signal Transduction Cell-cell Junction Positive Regulation Of Protein Localization To Membrane Schwann Cell Development Kinase Activity Protein Phosphatase Binding Intracellular Signaling Cassette Ruffle Membrane Protein Binding ERBB2 Signaling Pathway Signal Transduction Phosphatidylinositol Biosynthetic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Ephrin Receptor Binding SWI/SNF Complex Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Immune System Process Phosphatidylinositol Metabolic Process Multivesicular Body, Internal Vesicle Lumen Guanyl-nucleotide Exchange Factor Adaptor Activity Insulin-like Growth Factor Receptor Signaling Pathway Intermembrane Phospholipid Transfer Isoprenoid Binding T Cell Activation
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