CLNK and FAM217A

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		CLNK	FAM217A
Description		cytokine dependent hematopoietic cell linker	family with sequence similarity 217 member A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Protein-containing Complex Mast Cell Granule
	Molecular Function	Protein Binding Protein-containing Complex Binding	Protein Binding
	Biological Process	Positive Regulation Of Natural Killer Cell Cytokine Production Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Natural Killer Cell Activation Intracellular Signal Transduction Mast Cell Degranulation
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Family history of Alzheimer's disease ( 30617256) Gout ( 33832965) Resistance to antihypertensive treatment in hypertension ( 28222112) Rheumatoid arthritis ( 24390342 30423114) Systemic lupus erythematosus ( 28714469 33536424) Takayasu arteritis ( 25604533) Urate levels ( 31578528) Uterine fibroid size (maximum dimension) ( 30196971) Vitiligo ( 22561518)	Night sleep phenotypes ( 27126917)
Interacting Genes		30 interacting genes: ANKRD50 ARAP3 BMX COQ9 CRK CYB561D2 EGFR ERBB2 FAM217A GLIS3 GRB2 GSTCD JAKMIP1 LCP2 NME4 P4HA2 PACSIN3 PIK3R1 PIK3R3 PPP1R7 PTK7 RASSF1 RB1 RPAIN SFMBT1 SMARCD1 SOCS6 STK36 TXK WWOX	2 interacting genes: CLNK TEX11
Entrez ID		116449	222826
HPRD ID		14720	10789
Ensembl ID		ENSG00000109684	ENSG00000145975
Uniprot IDs		Q7Z7G1	Q8IXS0
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Kinase Binding ErbB-3 Class Receptor Binding Neurotrophin TRKA Receptor Binding 1-phosphatidylinositol-3-kinase Regulator Activity Protein Tyrosine Kinase Activity ERBB2-EGFR Signaling Pathway Phosphatidylinositol 3-kinase Complex Enzyme-linked Receptor Protein Signaling Pathway Phosphatidylinositol 3-kinase Complex, Class IA Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Activity Regulation Of Immune System Process Insulin Receptor Substrate Binding Regulation Of Cell Cycle G1/S Phase Transition Insulin-like Growth Factor Receptor Binding ERBB Signaling Pathway Insulin Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Ras Protein Signal Transduction Cell-cell Junction Positive Regulation Of Protein Localization To Membrane Schwann Cell Development Kinase Activity Protein Phosphatase Binding Intracellular Signaling Cassette Ruffle Membrane Protein Binding ERBB2 Signaling Pathway Signal Transduction Phosphatidylinositol Biosynthetic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Ephrin Receptor Binding SWI/SNF Complex Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Immune System Process Phosphatidylinositol Metabolic Process Multivesicular Body, Internal Vesicle Lumen Guanyl-nucleotide Exchange Factor Adaptor Activity Insulin-like Growth Factor Receptor Signaling Pathway Intermembrane Phospholipid Transfer Isoprenoid Binding T Cell Activation	Gene Conversion Male Meiosis Chromosome Segregation Meiotic Gene Conversion Mast Cell Granule Chiasma Assembly Central Element Regulation Of Natural Killer Cell Cytokine Production Negative Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Cytokine Production Meiotic Chromosome Segregation Synaptonemal Complex Programmed Cell Death Involved In Cell Development Resolution Of Meiotic Recombination Intermediates Synaptonemal Complex Assembly Synaptonemal Complex Organization Ectopic Germ Cell Programmed Cell Death Mast Cell Degranulation Reciprocal Meiotic Recombination Homologous Recombination Positive Regulation Of Natural Killer Cell Mediated Immunity Leukocyte Degranulation Regulation Of Natural Killer Cell Activation Chromosome Organization Involved In Meiotic Cell Cycle Condensed Nuclear Chromosome Nuclear Chromosome Segregation Male Meiotic Nuclear Division Lysosome Localization Regulation Of Natural Killer Cell Mediated Immunity Negative Regulation Of Reproductive Process Meiosis I Cell Cycle Process Meiotic Nuclear Division Nuclear Division Positive Regulation Of Cytokine Production Involved In Immune Response
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