PPP1R3C and NHLRC1

Number of citations of the paper that reports this interaction (PubMedID 18070875)
65

Data Source:
BioGRID (enzymatic study, two hybrid)

		PPP1R3C	NHLRC1
Description		protein phosphatase 1 regulatory subunit 3C	NHL repeat containing E3 ubiquitin protein ligase 1
Image			No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Cytosol	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase 1 Binding Protein Phosphatase Binding Molecular Adaptor Activity Glycogen Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Glycogen Metabolic Process Glycogen Biosynthetic Process Regulation Of Glycogen Biosynthetic Process	Protein Polyubiquitination Glycogen Metabolic Process Glycogen Biosynthetic Process Autophagy Regulation Of Gene Expression Protein Ubiquitination Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Response To Endoplasmic Reticulum Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization To Plasma Membrane
Pathways		Glycogen synthesis Myoclonic epilepsy of Lafora	Glycogen synthesis Myoclonic epilepsy of Lafora
Drugs
Diseases			Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS			Intrinsic epigenetic age acceleration ( 29374233)
Interacting Genes		13 interacting genes: APP EPM2A ERGIC1 LONRF1 LXN NHLRC1 PPP1CA PPP1CB PPP1CC PRKAB2 RHEB SGTA TLL2	8 interacting genes: AGL GYS1 NNAT PPP1R3C UBE2D1 UBE2D3 UBE2E1 UBE2H
Entrez ID		5507	378884
HPRD ID		04298	06995
Ensembl ID		ENSG00000119938	ENSG00000187566
Uniprot IDs		Q9UQK1	Q6VVB1
PDB IDs		7QF7 7QFA 7QFB 7QM2
Enriched GO Terms of Interacting Partners?		Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process PTW/PP1 Phosphatase Complex Energy Derivation By Oxidation Of Organic Compounds Phosphatase Activity Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Dephosphorylation Generation Of Precursor Metabolites And Energy Phosphoprotein Phosphatase Activity Carbohydrate Metabolic Process Circadian Regulation Of Gene Expression Protein Metabolic Process Response To Light Stimulus Regulation Of Circadian Rhythm Glycogen Biosynthetic Process Response To Lead Ion Transition Metal Ion Binding Circadian Rhythm Polysaccharide Biosynthetic Process Perikaryon Protein Phosphatase 1 Binding Dendritic Spine Response To Radiation Chromosome, Telomeric Region Protein Kinase Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Protein Metabolic Process Amyloid-beta Complex Presynapse Growth Cone Lamellipodium Postsynapse Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Hydrolase Activity Myosin-light-chain-phosphatase Activity Carbohydrate Phosphatase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Rhythmic Process Cytosol Positive Regulation Of Gliogenesis Regulation Of Carbohydrate Catabolic Process Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import	Ubiquitin Conjugating Enzyme Activity Glycogen Biosynthetic Process Polysaccharide Biosynthetic Process Protein K48-linked Ubiquitination Glycogen Metabolic Process Ubiquitin-protein Transferase Activity Energy Reserve Metabolic Process Polysaccharide Metabolic Process Protein Polyubiquitination Carbohydrate Biosynthetic Process Transferase Activity Inclusion Body Macromolecule Catabolic Process Macromolecule Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein K11-linked Ubiquitination Protein Modification By Small Protein Conjugation Protein Monoubiquitination Generation Of Precursor Metabolites And Energy Protein Modification Process Post-translational Protein Modification Negative Regulation Of BMP Signaling Pathway Isoamylase Complex 4-alpha-glucanotransferase Activity Amylo-alpha-1,6-glucosidase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Carbohydrate Metabolic Process Catabolic Process Glycogen Synthase Activity, Transferring Glucose-1-phosphate Proteasomal Protein Catabolic Process Regulation Of BMP Signaling Pathway Proteolysis Alpha-1,4-glucan Glucosyltransferase (UDP-glucose Donor) Activity Negative Regulation Of Cellular Response To Growth Factor Stimulus Cytosol Protein Lipoylation ISG15 Transferase Activity Protein Catabolic Process ATP Binding Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway ISG15-protein Conjugation Glycosyltransferase Activity Glycogen Binding D-glucose Binding Protein Metabolic Process Nucleotide Binding
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