PPP1R3C and TLL2

		PPP1R3C	TLL2
Description		protein phosphatase 1 regulatory subunit 3C	tolloid like 2
Image			No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Cytosol	Extracellular Region Extracellular Space
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase 1 Binding Protein Phosphatase Binding Molecular Adaptor Activity Glycogen Binding	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Glycogen Metabolic Process Glycogen Biosynthetic Process Regulation Of Glycogen Biosynthetic Process	Proteolysis Dorsal/ventral Pattern Formation Protein Processing Cell Differentiation Collagen Fibril Organization Negative Regulation Of Skeletal Muscle Tissue Growth
Pathways		Glycogen synthesis Myoclonic epilepsy of Lafora	Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils
Drugs			Methyl N-{[(1R)-1-({1-[(benzyloxy)carbonyl]-L-prolyl-6-ammonio-L-norleucyl}amino)-2-phenylethyl](hydroxy)phosphoryl}-L-alanyl-L-prolinate
Diseases
GWAS			Attention deficit hyperactivity disorder ( 18839057) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Platelet reactivity in response to clopidogrel treatment ( 32472697) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770)
Interacting Genes		13 interacting genes: APP EPM2A ERGIC1 LONRF1 LXN NHLRC1 PPP1CA PPP1CB PPP1CC PRKAB2 RHEB SGTA TLL2	5 interacting genes: DNTT HPSE2 PAPSS2 PPP1R3C RBP4
Entrez ID		5507	7093
HPRD ID		04298	05993
Ensembl ID		ENSG00000119938	ENSG00000095587
Uniprot IDs		Q9UQK1	Q9Y6L7
PDB IDs		7QF7 7QFA 7QFB 7QM2
Enriched GO Terms of Interacting Partners?		Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process PTW/PP1 Phosphatase Complex Energy Derivation By Oxidation Of Organic Compounds Phosphatase Activity Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Dephosphorylation Generation Of Precursor Metabolites And Energy Phosphoprotein Phosphatase Activity Carbohydrate Metabolic Process Circadian Regulation Of Gene Expression Protein Metabolic Process Response To Light Stimulus Regulation Of Circadian Rhythm Glycogen Biosynthetic Process Response To Lead Ion Transition Metal Ion Binding Circadian Rhythm Polysaccharide Biosynthetic Process Perikaryon Protein Phosphatase 1 Binding Dendritic Spine Response To Radiation Chromosome, Telomeric Region Protein Kinase Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Protein Metabolic Process Amyloid-beta Complex Presynapse Growth Cone Lamellipodium Postsynapse Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Hydrolase Activity Myosin-light-chain-phosphatase Activity Carbohydrate Phosphatase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Rhythmic Process Cytosol Positive Regulation Of Gliogenesis Regulation Of Carbohydrate Catabolic Process Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import	Nucleotidyltransferase Activity DNA Nucleotidylexotransferase Activity Carbohydrate Biosynthetic Process Vitamin A Import Into Cell 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process Sulfate Assimilation Sulfate Adenylyltransferase (ATP) Activity Adenylylsulfate Kinase Activity Heparanase Activity Retinol Transmembrane Transporter Activity Female Genitalia Morphogenesis Retinol Transport Hormone Metabolic Process Terpenoid Transport Urinary Bladder Development Embryonic Retina Morphogenesis In Camera-type Eye Glycogen Binding Retinoid Binding Retinal Binding Vagina Development DNA Polymerase Activity Carbohydrate Metabolic Process Protein Phosphatase Type 1 Complex Glycogen Biosynthetic Process Molecular Carrier Activity Genitalia Morphogenesis Heart Trabecula Formation Retinol Binding Lipid Import Into Cell Retinal Metabolic Process Negative Regulation Of Cardiac Muscle Cell Proliferation Female Genitalia Development Vitamin Transmembrane Transport Phototransduction, Visible Light 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Heparan Sulfate Proteoglycan Binding Detection Of Light Stimulus Involved In Visual Perception DNA-directed DNA Polymerase Activity Uterus Development Protein Phosphatase 1 Binding Polysaccharide Biosynthetic Process Detection Of Visible Light Maintenance Of Gastrointestinal Epithelium Negative Regulation Of Cardiac Muscle Tissue Growth DNA Modification Regulation Of Glycogen Biosynthetic Process Response To Muscle Activity Response To ATP Regulation Of Hormone Levels Negative Regulation Of Organ Growth
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