PLEKHB2 and EPN1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		PLEKHB2	EPN1
Description		pleckstrin homology domain containing B2	epsin 1
Image
GO Annotations	Cellular Component	Endosome Membrane Recycling Endosome Membrane	Nucleus Cytoplasm Endosome Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin Vesicle Coat
	Molecular Function	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding	Protein Binding Phospholipid Binding Lipid Binding Clathrin Binding Molecular Sequestering Activity
	Biological Process	Regulation Of Cell Differentiation	In Utero Embryonic Development Endocytosis Notch Signaling Pathway Female Pregnancy Embryonic Organ Development Negative Regulation Of Sprouting Angiogenesis
Pathways			EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			1,4-Dioxane 1D-myo-inositol 1,4,5-trisphosphate
Diseases
GWAS			Major depressive disorder ( 23377640)
Interacting Genes		54 interacting genes: ATF7IP BHLHE40 C1orf94 CD68 CDA CFC1 CFTR CLDN19 DAZAP2 DCUN1D1 EMP1 EMP3 EPN1 EPN2 FAM168A FOXD4L3 GGA3 GJB2 GLIS2 GPR45 HEY1 HEYL HGS HIVEP1 MAP3K1 MED25 MTURN NRGN NTAQ1 OTUB2 PIP4P1 PITX1 POGZ PROP1 RHBDD1 RPS27A RUNX1 SFT2D1 SNRPB STAM2 SYNGR1 TAX1BP1 TRARG1 UBA52 UBAC1 UBAP2 UBASH3A UBB UBC UBQLN2 UBXN6 UPF1 YOD1 ZFAND2A	24 interacting genes: AP2A1 AP2A2 CDK1 CEP126 CLTC CRMP1 DAZAP2 EPS15 EPS15L1 FBXO25 HIP1R LAPTM5 LITAF MAP3K1 MED31 PLEKHB2 REPS2 RNF11 SCNN1A SCNN1B SCNN1G SMURF1 TFAP2A ZBTB16
Entrez ID		55041	29924
HPRD ID		15144	06270
Ensembl ID		ENSG00000115762	ENSG00000063245
Uniprot IDs		A0A0A0MSE9 A0A0A0MSI4 B4DJB7 Q96CS7	Q9Y6I3
PDB IDs		3AJ4 3VIA	1INZ 1KYD
Enriched GO Terms of Interacting Partners?		Protein Tag Activity Endosome Membrane ESCRT-0 Complex Positive Regulation Of Macromolecule Metabolic Process Cytoplasm DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Macromolecule Catabolic Process Endocytic Vesicle Membrane Post-translational Protein Modification Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Autophagy Endosome Transport Via Multivesicular Body Sorting Pathway Ubiquitin Binding Clathrin Vesicle Coat ERAD Pathway Early Endosome Membrane Bleb Assembly Multivesicular Body Sorting Pathway Endosome Protein K11-linked Deubiquitination Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway	WW Domain Binding Clathrin-coated Pit Import Into Cell Sensory Perception Of Salty Taste Postsynaptic Neurotransmitter Receptor Internalization Clathrin Coat Of Coated Pit Sensory Perception Of Sour Taste Cellular Response To Vasopressin Cellular Response To Aldosterone Sodium Channel Complex Postsynaptic Endocytic Zone AP-2 Adaptor Complex Cellular Response To Mineralocorticoid Stimulus Ligand-gated Sodium Channel Activity Response To Aldosterone Endocytosis Clathrin Adaptor Activity Endolysosome Membrane Cellular Response To Acidic PH Receptor Internalization Clathrin Coat Assembly Clathrin-coated Vesicle Receptor-mediated Endocytosis Intracellular Sodium Ion Homeostasis Clathrin-coated Endocytic Vesicle Sodium Ion Import Across Plasma Membrane Response To Acidic PH Cellular Response To PH Vesicle-mediated Transport In Synapse Multicellular Organismal-level Water Homeostasis Apical Plasma Membrane Clathrin-dependent Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process Sensory Perception Of Taste Sodium Channel Activity Sodium Ion Homeostasis Response To Mineralocorticoid Synaptic Vesicle Endocytosis Response To PH Cytosolic Transport Presynaptic Endocytosis Clathrin Coat Of Trans-Golgi Network Vesicle Regulation Of Hyaluronan Biosynthetic Process Clathrin Light Chain Binding Cellular Response To Corticosteroid Stimulus Clathrin-coated Endocytic Vesicle Membrane Vesicle-mediated Transport Clathrin Adaptor Complex Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Multicellular Organismal-level Chemical Homeostasis
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