PLEKHB2 and GPR45

		PLEKHB2	GPR45
Description		pleckstrin homology domain containing B2	G protein-coupled receptor 45
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Membrane Recycling Endosome Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding	G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Regulation Of Cell Differentiation	Signal Transduction G Protein-coupled Receptor Signaling Pathway
Pathways			G alpha (s) signalling events
Drugs
Diseases
GWAS			Body mass index ( 26426971) Menarche (age at onset) ( 25231870 27182965)
Interacting Genes		54 interacting genes: ATF7IP BHLHE40 C1orf94 CD68 CDA CFC1 CFTR CLDN19 DAZAP2 DCUN1D1 EMP1 EMP3 EPN1 EPN2 FAM168A FOXD4L3 GGA3 GJB2 GLIS2 GPR45 HEY1 HEYL HGS HIVEP1 MAP3K1 MED25 MTURN NRGN NTAQ1 OTUB2 PIP4P1 PITX1 POGZ PROP1 RHBDD1 RPS27A RUNX1 SFT2D1 SNRPB STAM2 SYNGR1 TAX1BP1 TRARG1 UBA52 UBAC1 UBAP2 UBASH3A UBB UBC UBQLN2 UBXN6 UPF1 YOD1 ZFAND2A	4 interacting genes: OTX2 PLEKHB2 REV1 SULT1C4
Entrez ID		55041	11250
HPRD ID		15144	05325
Ensembl ID		ENSG00000115762	ENSG00000135973
Uniprot IDs		A0A0A0MSE9 A0A0A0MSI4 B4DJB7 Q96CS7	B5B0C1 Q9Y5Y3
PDB IDs		3AJ4 3VIA
Enriched GO Terms of Interacting Partners?		Protein Tag Activity Endosome Membrane ESCRT-0 Complex Positive Regulation Of Macromolecule Metabolic Process Cytoplasm DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Macromolecule Catabolic Process Endocytic Vesicle Membrane Post-translational Protein Modification Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Autophagy Endosome Transport Via Multivesicular Body Sorting Pathway Ubiquitin Binding Clathrin Vesicle Coat ERAD Pathway Early Endosome Membrane Bleb Assembly Multivesicular Body Sorting Pathway Endosome Protein K11-linked Deubiquitination Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway	Primitive Streak Formation Positive Regulation Of Embryonic Development Eukaryotic Initiation Factor 4E Binding Positive Regulation Of Gastrulation Regulation Of Gastrulation Doxorubicin Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Ethanol Metabolic Process Flavonoid Metabolic Process Sulfation Aryl Sulfotransferase Activity Ethanol Catabolic Process Error-free Translesion Synthesis Deoxycytidyl Transferase Activity Error-prone Translesion Synthesis DNA-directed DNA Polymerase Activity Translesion Synthesis Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Midbrain Development Dopaminergic Neuron Differentiation Alcohol Catabolic Process Postreplication Repair Sulfotransferase Activity Phosphatidylinositol-3,4,5-trisphosphate Binding DNA Synthesis Involved In DNA Repair Secondary Metabolic Process
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