PRPF39 and PRRC2B

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		PRPF39	PRRC2B
Description		pre-mRNA processing factor 39	proline rich coiled-coil 2B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Commitment Complex Nucleus U1 SnRNP U2-type Prespliceosome
	Molecular Function	Protein Binding Pre-mRNA 5'-splice Site Binding	RNA Binding Protein Binding
	Biological Process	MRNA 5'-splice Site Recognition RNA Processing MRNA Processing RNA Splicing	Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Lead levels ( 26025379)	Femur bone mineral density x serum urate levels interaction ( 34046847) Lung function ( 31902109) Urate levels ( 31578528)
Interacting Genes		15 interacting genes: ARF6 BANP CEBPA DHX30 DMRTB1 GTSE1 LARP4 MBNL1 PRRC2B QKI RBM22 RNU1-1 SF1 TOLLIP TRNAU1AP	48 interacting genes: AK8 ALG13 ANKHD1 APP ATN1 ATXN1 ATXN1L BAG4 BCAS2 CFAP77 CRK CTBP1 DAPK1 DDX11 DDX31 DIMT1 DMRTB1 DNAJC5 DPY30 EHMT2 ESS2 EXOSC1 EXOSC4 EXOSC7 FBXO7 GTF3C4 IPO5 LSM5 MRPL44 NIP7 NXF1 NXF5 PLPP7 PRPF39 QKI RBFOX2 RBPMS RERE RPL13 SETX SF1 SRPK2 SRSF4 TRNAU1AP TXNL4A UCK1 YTHDF1 YTHDF3
Entrez ID		55015	84726
HPRD ID		17913	13805
Ensembl ID		ENSG00000185246	ENSG00000288701
Uniprot IDs		Q86UA1	Q5JSZ5 Q9BU62
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding Protein Localization To Endosome Cytoplasmic Stress Granule MRNA Cis Splicing, Via Spliceosome RNA Splicing Erythrocyte Apoptotic Process Macrophage Differentiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding MRNA Processing Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Internal N(7)-methylguanine-containing RNA Reader Activity	RNA Binding Nucleus RNA Processing RNA Metabolic Process Nucleic Acid Binding RNA Splicing MRNA Metabolic Process Nucleolus MRNA Processing MRNA Binding Nucleoplasm Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Splicing, Via Transesterification Reactions Nucleolar Exosome (RNase Complex) Regulation Of MRNA Metabolic Process Cytoplasmic Stress Granule Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Macromolecule Metabolic Process Regulation Of RNA Splicing Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Regulation Of MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing POZ Domain Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Stress Granule Assembly Negative Regulation Of Macromolecule Metabolic Process MRNA Splice Site Recognition Exoribonuclease Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Spliceosomal Complex Nuclear RNA Export Factor Complex U4 SnRNA 3'-end Processing Protein-RNA Complex Assembly Cytoplasm Transcription Corepressor Activity Negative Regulation Of Metabolic Process Spliceosomal Complex Assembly Memory Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Nuclear MRNA Surveillance Nuclear Inclusion Body N6-methyladenosine-containing RNA Reader Activity
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