PPP1CC and SFRP1

Number of citations of the paper that reports this interaction (PubMedID 17123353)
50

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology, affinity chromatography technology)

		PPP1CC	SFRP1
Description		protein phosphatase 1 catalytic subunit gamma	secreted frizzled related protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Microtubule Organizing Center Cytosol Cytoskeleton Focal Adhesion Nuclear Speck Midbody Cleavage Furrow Protein-containing Complex Dendritic Spine PTW/PP1 Phosphatase Complex Presynapse Postsynapse Glutamatergic Synapse	Extracellular Region Extracellular Space Cytosol Plasma Membrane Cell Surface Extracellular Matrix Extracellular Exosome
	Molecular Function	RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Lamin Binding Protein Phosphatase 1 Binding Hydrolase Activity Phosphatase Activity Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Protein-containing Complex Binding Metal Ion Binding	Cysteine-type Endopeptidase Activity Frizzled Binding Protein Binding Heparin Binding Wnt-protein Binding Identical Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation MAPK Cascade Blastocyst Development Glycogen Metabolic Process Protein Dephosphorylation Spermatogenesis Neuron Differentiation Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Regulation Of Nucleocytoplasmic Transport Rhythmic Process Cell Division Positive Regulation Of Glial Cell Proliferation	Osteoblast Differentiation Ureteric Bud Development Somitogenesis Neural Tube Closure Positive Regulation Of Cell-matrix Adhesion Hematopoietic Progenitor Cell Differentiation Regionalization Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Female Gonad Development Cellular Response To Starvation Response To Xenobiotic Stimulus Dorsal/ventral Axis Specification Anterior/posterior Pattern Specification Regulation Of Cell Cycle Process Negative Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Projection Development Neural Crest Cell Fate Commitment Wnt Signaling Pathway Neural Tube Development Hemopoiesis Cell Differentiation Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Ossification Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Osteoclast Differentiation Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Osteoblast Proliferation Somatic Stem Cell Population Maintenance Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of B Cell Differentiation Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Osteoclast Differentiation Regulation Of Angiogenesis Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Development Of Primary Male Sexual Characteristics Negative Regulation Of Bone Remodeling Negative Regulation Of Fibroblast Proliferation Digestive Tract Morphogenesis Stem Cell Differentiation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Hematopoietic Stem Cell Differentiation Bone Trabecula Formation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Regulation Of Branching Involved In Prostate Gland Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Vitamin D Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Prostaglandin E Stimulus Cellular Response To Estrogen Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To X-ray Dopaminergic Neuron Differentiation Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To BMP Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Establishment Of Planar Polarity Wnt Signaling Pathway Involved In Somitogenesis Convergent Extension Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Triglyceride catabolism Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins RAF activation Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling Maturation of hRSV A proteins Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Drugs		9,10-Deepithio-9,10-Didehydroacanthifolicin Calyculin A Motuporin
Diseases
GWAS		Heart rate ( 23583979)	Academic attainment (English) ( 33594131) Anti-saccade response ( 29064472) Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Refractive astigmatism ( 30306274)
Interacting Genes		128 interacting genes: ABT1 ACAD8 AKAP11 ANKRD42 APIP APP ASH2L AURKA B4GAT1 BMPR2 BTBD10 C14orf180 C1QA C9orf50 CEP126 CLMN CLOCK CLTC CNST COPS5 CSNK1A1 CSNK1E CSNK2B CSRNP2 CTSL CYFIP1 DACT1 DEAF1 DELEC1 DYNLT4 DYRK4 EIF2AK2 ELP4 ENKD1 FBXW11 FTL FXYD6 GLB1L GOLGA7 GSTZ1 HCFC1 HDAC6 HMGN1 IFTAP IL3RA INSYN1 IRAK1 JAK2 KCTD20 KDM4D KRCC1 LMTK2 MAP4K4 MAPT MYO16 NAPEPLD NEK2 NMT2 NONO NRBP1 NUAK1 PHACTR4 PHC1 PIAS1 POLR1F PPP1R11 PPP1R15B PPP1R16A PPP1R18 PPP1R2 PPP1R2B PPP1R2C PPP1R35 PPP1R3A PPP1R3C PPP1R3D PPP1R7 PPP1R8 PPP1R9A PPP2R5C PRR16 RAF1 RB1 RIF1 RNF19B RORC RPL7 RPRD2 RRM1 RRP1B SAXO4 SDR39U1 SFRP1 SGCE SH3RF2 SHANK3 SMARCB1 SMG6 SPATC1L SPOCD1 STAM STARD9 SUMO2 TACC2 TBC1D19 TEFM TEX36 TLX1 TLX3 TMEM120A TNS1 TOPBP1 TOR1AIP1 TP53 TP53BP2 TPRN TRA2A VCP VSTM4 WBP11 YLPM1 YWHAZ ZDBF2 ZFYVE9 ZNF24 ZNF318 ZNF629 ZNF667	10 interacting genes: FZD6 IDO1 NHSL3 PPP1CA PPP1CC TMEM86B UBXN8 WNT1 WNT2 WNT4
Entrez ID		5501	6422
HPRD ID		08911	09165
Ensembl ID		ENSG00000186298	ENSG00000104332
Uniprot IDs		P36873	Q8N474
PDB IDs		1IT6 1JK7 1U32 2BCD 2BDX 4UT2 4UT3 5INB 5J28 7SD0 8B5R
Enriched GO Terms of Interacting Partners?		Protein Phosphatase 1 Binding Protein Phosphatase Inhibitor Activity Phosphatase Binding Protein Phosphatase Regulator Activity Protein Serine/threonine Kinase Activity Protein Phosphorylation Protein Serine/threonine Phosphatase Inhibitor Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Phosphatase Type 1 Complex Phosphorylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Viral Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Regulation Of Proteolysis Macromolecule Metabolic Process Nucleoplasm Protein Kinase Activity Positive Regulation Of Proteasomal Protein Catabolic Process Inclusion Body Assembly Glycogen Binding Disordered Domain Specific Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Generation Of Precursor Metabolites And Energy Microglial Cell Activation Protein Serine Kinase Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Phosphatase Binding Nucleus Glycogen Metabolic Process Leukocyte Activation Involved In Inflammatory Response Chromatin Remodeling Actin Binding Regulation Of Protein Metabolic Process Regulation Of Primary Metabolic Process Chromatin Organization Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process PML Body Type II Interferon-mediated Signaling Pathway Germ Cell Nucleus Polysaccharide Metabolic Process Regulation Of Circadian Rhythm Energy Reserve Metabolic Process Epigenetic Regulation Of Gene Expression DNA Damage Response Positive Regulation Of Nucleobase-containing Compound Metabolic Process Astrocyte Activation	Cell Proliferation In Midbrain Canonical Wnt Signaling Pathway Positive Regulation Of Dermatome Development Frizzled Binding PTW/PP1 Phosphatase Complex Wnt Signaling Pathway Regulation Of Embryonic Development Mammary Gland Epithelium Development Neural Precursor Cell Proliferation Midbrain Dopaminergic Neuron Differentiation Cell Population Proliferation Neuron Differentiation Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Embryonic Development Receptor Ligand Activity Tissue Morphogenesis Central Nervous System Neuron Differentiation Entrainment Of Circadian Clock By Photoperiod Morphogenesis Of A Branching Epithelium Protein Phosphatase 1 Binding Morphogenesis Of A Branching Structure Photoperiodism Entrainment Of Circadian Clock Cell Fate Commitment Developmental Induction Midbrain Development Dopaminergic Neuron Differentiation Cytokine Activity Branching Involved In Ureteric Bud Morphogenesis T Cell Differentiation In Thymus Cell Activation Non-canonical Wnt Signaling Pathway T Cell Activation Tube Morphogenesis Glycogen Metabolic Process Midbrain-hindbrain Boundary Maturation During Brain Development Cerebellum Formation Positive Regulation Of Fibroblast Proliferation Inner Ear Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Male Gonad Development Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Androgen Biosynthetic Process Metanephric Nephron Morphogenesis Negative Regulation Of Testicular Blood Vessel Morphogenesis D-lysine 5,6-aminomutase Activity Circadian Regulation Of Gene Expression Regulation Of Morphogenesis Of An Epithelium Morphogenesis Of An Epithelium Anatomical Structure Morphogenesis
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