SFRP1 and NHSL3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SFRP1	NHSL3
Description		secreted frizzled related protein 1	NHS like 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Plasma Membrane Cell Surface Extracellular Matrix Extracellular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Frizzled Binding Protein Binding Heparin Binding Wnt-protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Osteoblast Differentiation Ureteric Bud Development Somitogenesis Neural Tube Closure Positive Regulation Of Cell-matrix Adhesion Hematopoietic Progenitor Cell Differentiation Regionalization Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Female Gonad Development Cellular Response To Starvation Response To Xenobiotic Stimulus Dorsal/ventral Axis Specification Anterior/posterior Pattern Specification Regulation Of Cell Cycle Process Negative Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Projection Development Neural Crest Cell Fate Commitment Wnt Signaling Pathway Neural Tube Development Hemopoiesis Cell Differentiation Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Ossification Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Osteoclast Differentiation Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Osteoblast Proliferation Somatic Stem Cell Population Maintenance Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of B Cell Differentiation Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Osteoclast Differentiation Regulation Of Angiogenesis Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Development Of Primary Male Sexual Characteristics Negative Regulation Of Bone Remodeling Negative Regulation Of Fibroblast Proliferation Digestive Tract Morphogenesis Stem Cell Differentiation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Hematopoietic Stem Cell Differentiation Bone Trabecula Formation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Regulation Of Branching Involved In Prostate Gland Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Vitamin D Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Prostaglandin E Stimulus Cellular Response To Estrogen Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To X-ray Dopaminergic Neuron Differentiation Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To BMP Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Establishment Of Planar Polarity Wnt Signaling Pathway Involved In Somitogenesis Convergent Extension Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Cell Differentiation
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Drugs
Diseases
GWAS		Academic attainment (English) ( 33594131) Anti-saccade response ( 29064472) Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Refractive astigmatism ( 30306274)
Interacting Genes		10 interacting genes: FZD6 IDO1 NHSL3 PPP1CA PPP1CC TMEM86B UBXN8 WNT1 WNT2 WNT4	1 interacting genes: SFRP1
Entrez ID		6422	57648
HPRD ID		09165	18852
Ensembl ID		ENSG00000104332	ENSG00000162522
Uniprot IDs		Q8N474	Q9P206
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Proliferation In Midbrain Canonical Wnt Signaling Pathway Positive Regulation Of Dermatome Development Frizzled Binding PTW/PP1 Phosphatase Complex Wnt Signaling Pathway Regulation Of Embryonic Development Mammary Gland Epithelium Development Neural Precursor Cell Proliferation Midbrain Dopaminergic Neuron Differentiation Cell Population Proliferation Neuron Differentiation Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Embryonic Development Receptor Ligand Activity Tissue Morphogenesis Central Nervous System Neuron Differentiation Entrainment Of Circadian Clock By Photoperiod Morphogenesis Of A Branching Epithelium Protein Phosphatase 1 Binding Morphogenesis Of A Branching Structure Photoperiodism Entrainment Of Circadian Clock Cell Fate Commitment Developmental Induction Midbrain Development Dopaminergic Neuron Differentiation Cytokine Activity Branching Involved In Ureteric Bud Morphogenesis T Cell Differentiation In Thymus Cell Activation Non-canonical Wnt Signaling Pathway T Cell Activation Tube Morphogenesis Glycogen Metabolic Process Midbrain-hindbrain Boundary Maturation During Brain Development Cerebellum Formation Positive Regulation Of Fibroblast Proliferation Inner Ear Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Male Gonad Development Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Androgen Biosynthetic Process Metanephric Nephron Morphogenesis Negative Regulation Of Testicular Blood Vessel Morphogenesis D-lysine 5,6-aminomutase Activity Circadian Regulation Of Gene Expression Regulation Of Morphogenesis Of An Epithelium Morphogenesis Of An Epithelium Anatomical Structure Morphogenesis	Cellular Response To X-ray Wnt Signaling Pathway Involved In Somitogenesis Convergent Extension Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Development Of Primary Sexual Characteristics Regulation Of Midbrain Dopaminergic Neuron Differentiation Negative Regulation Of B Cell Differentiation Convergent Extension Involved In Axis Elongation Negative Regulation Of Osteoblast Proliferation Cellular Response To Vitamin D Regulation Of Dopaminergic Neuron Differentiation Negative Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Convergent Extension Involved In Somitogenesis Regulation Of Branching Involved In Prostate Gland Morphogenesis Regulation Of Establishment Of Planar Polarity Branching Involved In Prostate Gland Morphogenesis Convergent Extension Involved In Gastrulation Bone Trabecula Formation Positive Regulation Of Fibroblast Apoptotic Process Development Of Primary Male Sexual Characteristics Neural Crest Cell Fate Commitment Dorsal/ventral Axis Specification Cellular Response To Estrogen Stimulus Cellular Response To Prostaglandin E Stimulus Negative Regulation Of Bone Remodeling Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Fibroblast Apoptotic Process Digestive Tract Morphogenesis Positive Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Androgen Receptor Signaling Pathway Hematopoietic Stem Cell Differentiation Response To Vitamin D Regulation Of Osteoblast Proliferation Female Gonad Development Response To X-ray Dopaminergic Neuron Differentiation Response To Prostaglandin E Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Osteoclast Differentiation Cellular Response To Estradiol Stimulus Positive Regulation Of Focal Adhesion Assembly Wnt-protein Binding Cellular Response To BMP Stimulus Cellular Response To Prostaglandin Stimulus Negative Regulation Of B Cell Activation Regulation Of B Cell Differentiation Wnt Signaling Pathway, Planar Cell Polarity Pathway Frizzled Binding Prostate Gland Epithelium Morphogenesis
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