RASIP1 and ARFGAP1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RASIP1	ARFGAP1
Description		Ras interacting protein 1	ARF GTPase activating protein 1
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Golgi Stack Cell-cell Junction Protein-containing Complex Perinuclear Region Of Cytoplasm	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Synapse
	Molecular Function	Protein Binding Protein Homodimerization Activity GTPase Binding	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Angiogenesis Vasculogenesis Signal Transduction Negative Regulation Of Autophagy Positive Regulation Of Integrin Activation Negative Regulation Of Rho Protein Signal Transduction Regulation Of GTPase Activity Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Membrane Permeability Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity	Protein Transport Vesicle-mediated Transport Regulation Of Endocytosis Regulation Of ARF Protein Signal Transduction
Pathways			XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Alcohol consumption ( 31358974) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Bipolar disorder ( 21926972) Blood protein levels in cardiovascular risk ( 28369058) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cooked vegetable consumption ( 32066663) Crohn's disease ( 21102463 28067908) Dietary macronutrient intake ( 23372041) Estimated glomerular filtration rate ( 31015462) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) Lipoprotein (a) levels ( 33730874) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean platelet volume ( 27863252 32888494) Meat-related diet ( 32066663) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Platelet count ( 32888494) Pork consumption ( 32066663) Processed meat consumption ( 32066663) Retinal vascular caliber ( 21060863) Urinary albumin-to-creatinine ratio ( 31511532) Vitamin B levels in ischemic stroke ( 25147783) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		9 interacting genes: ARFGAP1 HRAS LDB2 MRAS RAP1A RAP2A RRAS RRAS2 UBC	40 interacting genes: AGTR1 APOB APOC3 APOE APP ARF1 ASB10 COPA COPS5 CRYAA CSNK1D CYTH2 FOS GABARAPL1 GABARAPL2 GGCX GRN HRAS KDELR1 KRTAP10-9 KRTAP3-2 KRTAP9-2 LRRK2 MAP1LC3B MED27 PRKACB RAB23 RABGAP1L RASIP1 REEP5 RFC3 RGS2 RPL11 SLC25A21-AS1 SLC6A1 SMN1 SNCA TK1 TMED2 TRIM23
Entrez ID		54922	55738
HPRD ID		15214	06443
Ensembl ID		ENSG00000105538	ENSG00000101199
Uniprot IDs		Q5U651 Q7L251 Q8IUR2	Q53F62 Q8N6T3
PDB IDs		5KHO 5KHQ	3DWD 3O47
Enriched GO Terms of Interacting Partners?		GDP Binding Small GTPase-mediated Signal Transduction GTPase Activity GTP Binding G Protein Activity Ras Protein Signal Transduction Schwann Cell Migration Intracellular Signaling Cassette Rap Protein Signal Transduction Positive Regulation Of Vasculogenesis Regulation Of Vasculogenesis Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Hydrolase Activity Regulation Of Glial Cell Migration Regulation Of Cell Migration Nucleotide Binding Regulation Of Cell Motility Intracellular Signal Transduction Regulation Of Protein Localization To Synapse Regulation Of Locomotion Regulation Of Receptor Localization To Synapse Glial Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Plasma Membrane Regulation Of MAPK Cascade Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Projection Organization GTPase Complex Response To Antineoplastic Agent Phospholipase C Activator Activity Negative Regulation Of Schwann Cell Migration Positive Regulation Of Schwann Cell Migration Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Component Biogenesis Regulation Of JNK Cascade Positive Regulation Of Microvillus Assembly Regulation Of Protein Localization To Cell Periphery Oncogene-induced Cell Senescence Golgi Membrane Regulation Of Protein Localization To Membrane Golgi Apparatus Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Synaptic Vesicle Exocytosis Guanyl-nucleotide Exchange Factor Complex Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Negative Regulation Of Glial Cell Migration LIM Domain Binding	Intermediate-density Lipoprotein Particle Protein-containing Complex Organization Phospholipid Binding Vesicle-mediated Transport Very-low-density Lipoprotein Particle Golgi Apparatus Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Protein-containing Complex Assembly Lipoprotein Metabolic Process Plasma Lipoprotein Particle Remodeling Cellular Response To Nitrogen Starvation Protein-containing Complex Remodeling Cellular Component Assembly Regulation Of Proteolysis Cytoplasmic Vesicle Beta-tubulin Binding Vacuole Organization Chylomicron Phosphatidylethanolamine Binding Low-density Lipoprotein Particle Chylomicron Remnant Negative Regulation Of Transport Locomotory Exploration Behavior Lipoprotein Particle Low-density Lipoprotein Particle Remodeling COPI-coated Vesicle Membrane Endocytosis Regulation Of Small Molecule Metabolic Process Regulation Of Neuronal Synaptic Plasticity Import Into Cell Cytosol Golgi Membrane Growth Cone Establishment Of Protein Localization Regulation Of Protein Catabolic Process Protein Transport Establishment Of Localization In Cell Cellular Response To Nutrient Levels Low-density Lipoprotein Particle Receptor Binding Regulation Of Long-term Neuronal Synaptic Plasticity Astrocyte Activation Involved In Immune Response Plasma Lipoprotein Particle Clearance Autophagosome Neutral Lipid Metabolic Process Cholesterol Efflux Microglial Cell Activation Positive Regulation Of Inflammatory Response Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance
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