ARFGAP1 and SLC6A1

Number of citations of the paper that reports this interaction (PubMedID 19020038)
43

Data Source:
BioGRID (pull down)

		ARFGAP1	SLC6A1
Description		ARF GTPase activating protein 1	solute carrier family 6 member 1
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Synapse	Plasma Membrane Cell Surface Membrane Axon Cell Projection Neuronal Cell Body Synapse Presynapse GABA-ergic Synapse
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Amino Acid:sodium Symporter Activity Gamma-aminobutyric Acid:sodium:chloride Symporter Activity Protein Binding Gamma-aminobutyric Acid Transmembrane Transporter Activity Symporter Activity Sodium:chloride Symporter Activity Transmembrane Transporter Activity Metal Ion Binding
	Biological Process	Protein Transport Vesicle-mediated Transport Regulation Of Endocytosis Regulation Of ARF Protein Signal Transduction	Amino Acid Transmembrane Transport Neurotransmitter Transport Amino Acid Transport Chemical Synaptic Transmission Memory Associative Learning Sodium Ion Transmembrane Transport Synapse Organization Gamma-aminobutyric Acid Reuptake Gamma-aminobutyric Acid Import Inorganic Anion Import Across Plasma Membrane Sodium Ion Import Across Plasma Membrane Neurotransmitter Reuptake Transport Across Blood-brain Barrier Chloride Transmembrane Transport
Pathways		XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Clathrin-mediated endocytosis	SLC-mediated transport of neurotransmitters Reuptake of GABA
Drugs			Tiagabine Guvacine
Diseases
GWAS			Body fat percentage ( 31752434) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Loneliness (linear analysis) ( 27629369) Longitudinal alcohol consumption ( 26081443) Lung function ( 31902109) Refractive error ( 32231278) Response to Vitamin E supplementation ( 22437554)
Interacting Genes		40 interacting genes: AGTR1 APOB APOC3 APOE APP ARF1 ASB10 COPA COPS5 CRYAA CSNK1D CYTH2 FOS GABARAPL1 GABARAPL2 GGCX GRN HRAS KDELR1 KRTAP10-9 KRTAP3-2 KRTAP9-2 LRRK2 MAP1LC3B MED27 PRKACB RAB23 RABGAP1L RASIP1 REEP5 RFC3 RGS2 RPL11 SLC25A21-AS1 SLC6A1 SMN1 SNCA TK1 TMED2 TRIM23	8 interacting genes: ARFGAP1 DRD2 HSF2BP HTR6 HUNK OXNAD1 SNCA STX1A
Entrez ID		55738	6529
HPRD ID		06443	00664
Ensembl ID		ENSG00000101199	ENSG00000157103
Uniprot IDs		Q53F62 Q8N6T3	A0A2R8Y4I3 B7Z3C5 P30531
PDB IDs		3DWD 3O47	7SK2 7Y7V 7Y7W 7Y7Y 7Y7Z
Enriched GO Terms of Interacting Partners?		Intermediate-density Lipoprotein Particle Protein-containing Complex Organization Phospholipid Binding Vesicle-mediated Transport Very-low-density Lipoprotein Particle Golgi Apparatus Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Protein-containing Complex Assembly Lipoprotein Metabolic Process Plasma Lipoprotein Particle Remodeling Cellular Response To Nitrogen Starvation Protein-containing Complex Remodeling Cellular Component Assembly Regulation Of Proteolysis Cytoplasmic Vesicle Beta-tubulin Binding Vacuole Organization Chylomicron Phosphatidylethanolamine Binding Low-density Lipoprotein Particle Chylomicron Remnant Negative Regulation Of Transport Locomotory Exploration Behavior Lipoprotein Particle Low-density Lipoprotein Particle Remodeling COPI-coated Vesicle Membrane Endocytosis Regulation Of Small Molecule Metabolic Process Regulation Of Neuronal Synaptic Plasticity Import Into Cell Cytosol Golgi Membrane Growth Cone Establishment Of Protein Localization Regulation Of Protein Catabolic Process Protein Transport Establishment Of Localization In Cell Cellular Response To Nutrient Levels Low-density Lipoprotein Particle Receptor Binding Regulation Of Long-term Neuronal Synaptic Plasticity Astrocyte Activation Involved In Immune Response Plasma Lipoprotein Particle Clearance Autophagosome Neutral Lipid Metabolic Process Cholesterol Efflux Microglial Cell Activation Positive Regulation Of Inflammatory Response Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance	Regulation Of Catecholamine Secretion Dopamine Uptake Involved In Synaptic Transmission Regulation Of Amine Transport Regulation Of Dopamine Uptake Involved In Synaptic Transmission Neurotransmitter Transport Catecholamine Uptake Dopamine Uptake SNARE Complex Assembly Synaptic Transmission, Dopaminergic Synapse Synaptic Vesicle Membrane Behavioral Response To Cocaine Dopamine Transport Neurotransmitter Reuptake Positive Regulation Of Synaptic Transmission Regulation Of Neurotransmitter Uptake Positive Regulation Of Neurotransmitter Secretion Regulation Of Dopamine Secretion Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Vesicle-mediated Transport Monoamine Transport Neurotransmitter Uptake Dopamine Metabolic Process Response To Iron Ion Synaptic Vesicle Exocytosis Synaptic Vesicle Endocytosis Telencephalon Cell Migration Response To Cocaine Catecholamine Metabolic Process Presynaptic Endocytosis Forebrain Cell Migration Positive Regulation Of Secretion By Cell Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Chemical Synaptic Transmission Axon Terminus Regulation Of Endocytosis Positive Regulation Of Secretion Excitatory Postsynaptic Potential Trans-synaptic Signaling Biogenic Amine Metabolic Process Synaptic Signaling Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity SNARE Binding Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Myosin Head/neck Binding Receptor Internalization
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