DPP8 and AFF3

		DPP8	AFF3
Description		dipeptidyl peptidase 8	ALF transcription elongation factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm Cytosol Nuclear Body Super Elongation Complex
	Molecular Function	Aminopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Dipeptidyl-peptidase Activity Hydrolase Activity	DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity
	Biological Process	Proteolysis Apoptotic Process Immune Response Negative Regulation Of Programmed Cell Death Protein Maturation CARD8 Inflammasome Complex Assembly Pyroptotic Cell Death NLRP1 Inflammasome Complex Assembly	Regulation Of DNA-templated Transcription Regulation Of Gene Expression Response To Tumor Necrosis Factor Embryonic Hindlimb Morphogenesis
Pathways
Drugs
Diseases
GWAS		Basophil percentage of white cells ( 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Hemoglobin levels ( 32327693) Mean corpuscular hemoglobin ( 20139978 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Red blood cell count ( 29403010 32888494)	A body shape index ( 34021172) Adult body size ( 32376654) Age at first birth ( 27798627) Albumin-globulin ratio ( 29403010) Apolipoprotein A1 levels ( 32203549) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 34103634) Autoimmune traits (pleiotropy) ( 30572963) Cannabis dependence symptom count ( 27028160) Celiac disease ( 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Extremely high intelligence ( 29520040) Gastroesophageal reflux disease ( 31527586 34187846) General cognitive ability ( 29844566) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 31217584) Hip circumference adjusted for BMI ( 34021172) Household income ( 27818178) Household income (MTAG) ( 31844048) IgG levels ( 28628107) Immature fraction of reticulocytes ( 32888494) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29617998) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes ( 27647854) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Multisite chronic pain ( 33830993) Non-albumin protein levels ( 29403010) Number of children ever born ( 27798627) Plateletcrit ( 27863252 32888494) Red blood cell count ( 27863252) Refractive astigmatism ( 30306274) Regular attendance at a religious group ( 29970889) Rheumatoid arthritis ( 24390342 30572963 24782177 23143596 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Serum total protein levels ( 29403010) Triglyceride levels ( 34074324) Type 1 diabetes ( 25751624 34127860 17554260) Type 1 diabetes nephropathy ( 23028342) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		1 interacting genes: AFF3	5 interacting genes: DPP8 GPR137B IL18R1 IL18RAP ST6GAL2
Entrez ID		54878	3899
HPRD ID		07076	03272
Ensembl ID		ENSG00000074603	ENSG00000144218
Uniprot IDs		A8K4U2 B4DLA8 Q6V1X1	P51826 Q8NAP7
PDB IDs		6EOO 6EOP 6EOS 6EOT 6HP8 6QZW 6TRW 6TRX 7A3G 7A3I 7A3J 7A3K 7A3L 7AYQ 7AYR 7OR4 7OZ7 7SVM 7SVO
Enriched GO Terms of Interacting Partners?		Super Elongation Complex Hindlimb Morphogenesis Embryonic Hindlimb Morphogenesis Limb Morphogenesis Embryonic Limb Morphogenesis Response To Tumor Necrosis Factor Double-stranded DNA Binding	Interleukin-18 Receptor Complex Interleukin-18 Receptor Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Interleukin-18-mediated Signaling Pathway Cellular Response To Interleukin-18 Positive Regulation Of NF-kappaB Transcription Factor Activity Inflammatory Response Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Lymphocyte Mediated Immunity Interleukin-18 Binding Beta-galactoside Alpha-2,6-sialyltransferase Activity Response To Interleukin-18 Regulation Of DNA-binding Transcription Factor Activity Regulation Of Lymphocyte Mediated Immunity CARD8 Inflammasome Complex Assembly Positive Regulation Of Protein Localization To Lysosome Positive Regulation Of Immune Effector Process Signaling Receptor Activity Interleukin-1 Receptor Activity Positive Regulation Of T-helper 1 Cell Cytokine Production NLRP1 Inflammasome Complex Assembly Immune Response Adaptive Immune Response Sialylation Dipeptidyl-peptidase Activity Negative Regulation Of Bone Resorption Defense Response T-helper 1 Cell Differentiation Pyroptotic Cell Death Negative Regulation Of Bone Remodeling Sialyltransferase Activity Cytokine-mediated Signaling Pathway Positive Regulation Of T-helper 1 Type Immune Response Regulation Of Immune System Process Hydrolase Activity Neutrophil Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of T Cell Cytokine Production Aminopeptidase Activity Negative Regulation Of Osteoclast Differentiation
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