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AFF3
Description
ALF transcription elongation factor 3
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Nuclear Body
Super Elongation Complex
Molecular Function
DNA Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Biological Process
Regulation Of DNA-templated Transcription
Regulation Of Gene Expression
Response To Tumor Necrosis Factor
Embryonic Hindlimb Morphogenesis
Pathways
Drugs
Diseases
GWAS
A body shape index (
34021172
)
Adult body size (
32376654
)
Age at first birth (
27798627
)
Albumin-globulin ratio (
29403010
)
Apolipoprotein A1 levels (
32203549
)
Arthritis (juvenile idiopathic) (
33106285
)
Asthma (
34103634
)
Autoimmune traits (pleiotropy) (
30572963
)
Cannabis dependence symptom count (
27028160
)
Celiac disease (
30572963
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Cognitive ability (
29186694
)
Cognitive ability (MTAG) (
29186694
)
Extremely high intelligence (
29520040
)
Gastroesophageal reflux disease (
31527586
34187846
)
General cognitive ability (
29844566
)
Hand grip strength (
29691431
)
HDL cholesterol levels (
32203549
)
Heel bone mineral density x serum urate levels interaction (
34046847
)
Height (
31217584
)
Hip circumference adjusted for BMI (
34021172
)
Household income (
27818178
)
Household income (MTAG) (
31844048
)
IgG levels (
28628107
)
Immature fraction of reticulocytes (
32888494
)
Intelligence (
28530673
)
Intelligence (MTAG) (
29326435
)
Intraocular pressure (
29617998
)
Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) (
23603761
)
Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes (
27647854
)
Mean corpuscular volume (
32888494
)
Mean platelet volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Multisite chronic pain (
33830993
)
Non-albumin protein levels (
29403010
)
Number of children ever born (
27798627
)
Plateletcrit (
27863252
32888494
)
Red blood cell count (
27863252
)
Refractive astigmatism (
30306274
)
Regular attendance at a religious group (
29970889
)
Rheumatoid arthritis (
24390342
30572963
24782177
23143596
30423114
)
Rheumatoid arthritis (ACPA-positive) (
24532676
23143596
)
Serum total protein levels (
29403010
)
Triglyceride levels (
34074324
)
Type 1 diabetes (
25751624
34127860
17554260
)
Type 1 diabetes nephropathy (
23028342
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Novel Interacting Genes
5 novel interacting genes:
DPP8
GPR137B
IL18R1
IL18RAP
ST6GAL2
Interacting Genes
5 interacting genes:
DPP8
GPR137B
IL18R1
IL18RAP
ST6GAL2
Entrez ID
3899
HPRD ID
03272
Ensembl ID
ENSG00000144218
Uniprot IDs
P51826
Q8NAP7
PDB IDs
Enriched GO Terms of Interacting Partners
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Interleukin-18 Receptor Complex
Interleukin-18 Receptor Activity
NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
Interleukin-18-mediated Signaling Pathway
Cellular Response To Interleukin-18
Positive Regulation Of NF-kappaB Transcription Factor Activity
Inflammatory Response
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Lymphocyte Mediated Immunity
Interleukin-18 Binding
Beta-galactoside Alpha-2,6-sialyltransferase Activity
Response To Interleukin-18
Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Lymphocyte Mediated Immunity
CARD8 Inflammasome Complex Assembly
Positive Regulation Of Protein Localization To Lysosome
Positive Regulation Of Immune Effector Process
Signaling Receptor Activity
Interleukin-1 Receptor Activity
Positive Regulation Of T-helper 1 Cell Cytokine Production
NLRP1 Inflammasome Complex Assembly
Immune Response
Adaptive Immune Response
Sialylation
Dipeptidyl-peptidase Activity
Negative Regulation Of Bone Resorption
Defense Response
T-helper 1 Cell Differentiation
Pyroptotic Cell Death
Negative Regulation Of Bone Remodeling
Sialyltransferase Activity
Cytokine-mediated Signaling Pathway
Positive Regulation Of T-helper 1 Type Immune Response
Regulation Of Immune System Process
Hydrolase Activity
Neutrophil Activation
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of T Cell Cytokine Production
Aminopeptidase Activity
Negative Regulation Of Osteoclast Differentiation
Tagcloud
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