DIRAS2 and RIPPLY1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DIRAS2	RIPPLY1
Description		DIRAS family GTPase 2	ripply transcriptional repressor 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleus
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding	Protein Binding
	Biological Process	Signal Transduction Positive Regulation Of MAP Kinase Activity	Negative Regulation Of Transcription By RNA Polymerase II Somite Specification Embryonic Pattern Specification Somite Rostral/caudal Axis Specification Negative Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases
GWAS		Cognitive test performance ( 17903297) Logical memory (immediate recall) in Alzheimer's disease dementia ( 29274321) Multiple sclerosis ( 31604244) Protein quantitative trait loci ( 18464913)	Alcoholic chronic pancreatitis ( 28754779) Pancreatitis ( 23143602)
Interacting Genes		2 interacting genes: RIPPLY1 UNC45A	44 interacting genes: AVPI1 BEND7 CFAP58 CTNNA3 DCAF15 DIRAS2 FHL2 GRAPL GRHL3 H3-4 HAND2 HDAC7 IRAK1BP1 KRT34 MCCD1 MDFI MED19 MEOX2 NDUFB7 PATZ1 PBX4 PFDN5 PLAGL2 PRR20A PRR20B PRR20C PRR20D PRR20E PTTG2 RBPMS REL RHOH RNF144B SAPCD1 THAP1 TRAF1 TRAF2 TRAF3 USP6 VAC14 VGLL1 ZMYND12 ZNF620 ZNF784
Entrez ID		54769	92129
HPRD ID		09711
Ensembl ID		ENSG00000165023	ENSG00000147223
Uniprot IDs		Q96HU8	Q0D2K3
PDB IDs		2ERX 6NAZ
Enriched GO Terms of Interacting Partners?		Somite Rostral/caudal Axis Specification Somite Specification Segment Specification Hsp90 Protein Binding Anterior/posterior Axis Specification Embryonic Axis Specification	Signaling Adaptor Activity Thioesterase Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Tumor Necrosis Factor Receptor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Sequence-specific DNA Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway
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