RIPPLY1 and USP6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RIPPLY1	USP6
Description		ripply transcriptional repressor 1	ubiquitin specific peptidase 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytoplasm Lysosome Endosome Golgi Apparatus Plasma Membrane Membrane Recycling Endosome Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Protein Binding	Nucleic Acid Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Calmodulin Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Somite Specification Embryonic Pattern Specification Somite Rostral/caudal Axis Specification Negative Regulation Of DNA-templated Transcription	Proteolysis Protein Deubiquitination Protein Modification Process Regulation Of Vesicle-mediated Transport Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Pathways
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Pancreatitis ( 23143602)	PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575)
Interacting Genes		44 interacting genes: AVPI1 BEND7 CFAP58 CTNNA3 DCAF15 DIRAS2 FHL2 GRAPL GRHL3 H3-4 HAND2 HDAC7 IRAK1BP1 KRT34 MCCD1 MDFI MED19 MEOX2 NDUFB7 PATZ1 PBX4 PFDN5 PLAGL2 PRR20A PRR20B PRR20C PRR20D PRR20E PTTG2 RBPMS REL RHOH RNF144B SAPCD1 THAP1 TRAF1 TRAF2 TRAF3 USP6 VAC14 VGLL1 ZMYND12 ZNF620 ZNF784	18 interacting genes: ANKRD11 ANKRD44 APP ATXN7L3 CABP2 CALM2 CDC42 EXOSC8 JAK1 JUN MDFI MYL2 RAB33B RAC1 RIPPLY1 TFIP11 UBC ZNF76
Entrez ID		92129	9098
HPRD ID			06827
Ensembl ID		ENSG00000147223	ENSG00000129204
Uniprot IDs		Q0D2K3	P35125
PDB IDs
Enriched GO Terms of Interacting Partners?		Signaling Adaptor Activity Thioesterase Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Tumor Necrosis Factor Receptor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Sequence-specific DNA Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway	Anatomical Structure Morphogenesis Thioesterase Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process G Protein Activity Acetylcholine Receptor Activator Activity Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Growth Cone Lamellipodium Neuron Projection Organization Intracellular Signal Transduction Regulation Of Nitric Oxide Biosynthetic Process Postsynapse Regulation Of Response To Calcium Ion Regulation Of Synaptic Plasticity Macrophage Activation Intracellular Signaling Cassette Amylin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Neuron Projection Development Regulation Of Postsynapse Organization Endocytosis Lipoprotein Particle Dendrite Development Positive Regulation Of Protein Import Microglial Cell Activation Regulation Of Nitric Oxide Metabolic Process Regulation Of MAPK Cascade Leukocyte Activation Involved In Inflammatory Response Supramolecular Fiber Organization Calcium Channel Regulator Activity Substantia Nigra Development Neural Nucleus Development Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Sarcomere Positive Regulation Of Lamellipodium Organization Positive Regulation Of Lamellipodium Assembly Heart Process Wnt Signaling Pathway, Planar Cell Polarity Pathway GTP-dependent Protein Binding Heart Contraction Positive Regulation Of Stress Fiber Assembly Regulation Of Lamellipodium Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Phagocytosis, Engulfment Regulation Of Substrate Adhesion-dependent Cell Spreading Membrane Invagination GBD Domain Binding
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