MPHOSPH8 and RANBP9

Number of citations of the paper that reports this interaction (PubMedID 12559565)
0

Data Source:
HPRD (two hybrid)

		MPHOSPH8	RANBP9
Description		M-phase phosphoprotein 8	RAN binding protein 9
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GO Annotations	Cellular Component	Nucleosome Heterochromatin Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Plasma Membrane	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane Membrane Nuclear Body
	Molecular Function	Chromatin Binding Protein Binding Histone H3K9me2/3 Reader Activity	Protein Binding Enzyme Binding Small GTPase Binding
	Biological Process	Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of Gene Expression, Epigenetic Constitutive Heterochromatin Formation Transposable Element Silencing By Heterochromatin Formation	Cytoskeleton Organization Microtubule Nucleation Protein-containing Complex Assembly Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Pathways		Negative Regulation of CDH1 Gene Transcription Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	L1CAM interactions RAF/MAP kinase cascade MET activates RAS signaling Regulation of pyruvate metabolism
Drugs
Diseases
GWAS		Colorectal cancer ( 34062886)	Breast cancer ( 23535729 29059683)
Interacting Genes		5 interacting genes: H3C1 MTRNR2L1 RANBP9 SH3BP4 SIRT1	67 interacting genes: ADAP1 ADAP2 APC AR ATM AXL BACE1 BRCA1 BTG3 CACNA1G CALB1 CBR1 CBR3 CBS CCND1 CDK11B CDKN1A CFAP298 CLEC7A DDX4 DISC1 DYRK1B ENTPD1 ESR1 EXOC2 FMR1 GATD3 GID8 GRIK1 HIPK2 HMBS HNF4G ITGAL ITGB2 L1CAM LCOR LMNA MAPK6 MET MORC3 MPHOSPH8 NCOA6 NCOR2 NSRP1 PPARD PPARG PPP1CA PRKACA RAF1 RAN S100A7 SMAD2 SMAD3 SMAD9 SOD1 SOS1 SPOP SPP1 TFRC THRA THRB TP53 TP73 UCHL1 USP11 WNK1 ZBED1
Entrez ID		54737	10048
HPRD ID		13682	04835
Ensembl ID		ENSG00000196199	ENSG00000010017
Uniprot IDs		Q99549	Q96S59
PDB IDs		3LWE 3QO2 3R93 3SVM 6V2S 7M5U 8QFB	5JI7 5JI9 5JIU 7NSC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of TOR Signaling NAD-dependent Protein Decrotonylase Activity Histone H4K12 Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Maintenance Of Nucleus Location Histone Decrotonylase Activity, NAD-dependent Histone H3K14 Deacetylase Activity, NAD-dependent Negative Regulation Of Cellular Response To Testosterone Stimulus Histone H3K Deacetylase Activity NAD-dependent Protein Lysine Delactylase Activity Regulation Of Cellular Response To Testosterone Stimulus Behavioral Response To Starvation Negative Regulation Of Peptidyl-lysine Acetylation Histone H4K16 Deacetylase Activity, NAD-dependent Histone H3K9 Deacetylase Activity, NAD-dependent NAD-dependent Protein-lysine Depropionylase Activity Negative Regulation Of Prostaglandin Biosynthetic Process Protein Depropionylation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macrophage Apoptotic Process ENoSc Complex Regulation Of TOR Signaling Positive Regulation Of CAMP-dependent Protein Kinase Activity Amino Acid Import Negative Regulation Of Protein Acetylation Positive Regulation Of Autophagy Negative Regulation Of Triglyceride Biosynthetic Process Triglyceride Mobilization Pyrimidine Dimer Repair By Nucleotide-excision Repair HLH Domain Binding Histone Deacetylase Activity, NAD-dependent Regulation Of CAMP-dependent Protein Kinase Activity RDNA Heterochromatin Keratin Filament Binding RDNA Heterochromatin Formation Regulation Of Endodeoxyribonuclease Activity Stress-induced Premature Senescence NAD-dependent Protein Lysine Deacetylase Activity Epigenetic Regulation Of Gene Expression Small GTPase Binding Ovulation From Ovarian Follicle Regulation Of Bile Acid Biosynthetic Process Pyrimidine Dimer Repair Regulation Of Transcription By Glucose Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Single Strand Break Repair Subtelomeric Heterochromatin Formation Chromatin Silencing Complex Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore UV-damage Excision Repair	Developmental Process Cellular Developmental Process Animal Organ Development Regulation Of Programmed Cell Death Nucleoplasm Protein-containing Complex Binding Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Nuclear Receptor Activity Enzyme Binding Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Biological Quality Regulation Of Apoptotic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Protein Kinase Binding Regulation Of MiRNA Transcription Regulation Of Gene Expression Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Molecular Condensate Scaffold Activity Cell Surface Receptor Signaling Pathway Transcription Coactivator Binding Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of MiRNA Transcription Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Response To Stress Nucleus Positive Regulation Of RNA Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Programmed Cell Death Ubiquitin Protein Ligase Binding Chromatin Binding Regulation Of Growth Apoptotic Signaling Pathway
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