MPHOSPH8

Description		M-phase phosphoprotein 8
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GO Annotations	Cellular Component	Nucleosome Heterochromatin Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Chromatin Binding Protein Binding Histone H3K9me2/3 Reader Activity
	Biological Process	Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of Gene Expression, Epigenetic Constitutive Heterochromatin Formation Transposable Element Silencing By Heterochromatin Formation
Pathways		Negative Regulation of CDH1 Gene Transcription Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Drugs
Diseases
GWAS		Colorectal cancer ( 34062886)
Novel Interacting Genes		5 novel interacting genes: H3C1 MTRNR2L1 RANBP9 SH3BP4 SIRT1
Interacting Genes		5 interacting genes: H3C1 MTRNR2L1 RANBP9 SH3BP4 SIRT1
Entrez ID		54737
HPRD ID		13682
Ensembl ID		ENSG00000196199
Uniprot IDs		Q99549
PDB IDs		3LWE 3QO2 3R93 3SVM 6V2S 7M5U 8QFB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of TOR Signaling NAD-dependent Protein Decrotonylase Activity Histone H4K12 Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Maintenance Of Nucleus Location Histone Decrotonylase Activity, NAD-dependent Histone H3K14 Deacetylase Activity, NAD-dependent Negative Regulation Of Cellular Response To Testosterone Stimulus Histone H3K Deacetylase Activity NAD-dependent Protein Lysine Delactylase Activity Regulation Of Cellular Response To Testosterone Stimulus Behavioral Response To Starvation Negative Regulation Of Peptidyl-lysine Acetylation Histone H4K16 Deacetylase Activity, NAD-dependent Histone H3K9 Deacetylase Activity, NAD-dependent NAD-dependent Protein-lysine Depropionylase Activity Negative Regulation Of Prostaglandin Biosynthetic Process Protein Depropionylation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macrophage Apoptotic Process ENoSc Complex Regulation Of TOR Signaling Positive Regulation Of CAMP-dependent Protein Kinase Activity Amino Acid Import Negative Regulation Of Protein Acetylation Positive Regulation Of Autophagy Negative Regulation Of Triglyceride Biosynthetic Process Triglyceride Mobilization Pyrimidine Dimer Repair By Nucleotide-excision Repair HLH Domain Binding Histone Deacetylase Activity, NAD-dependent Regulation Of CAMP-dependent Protein Kinase Activity RDNA Heterochromatin Keratin Filament Binding RDNA Heterochromatin Formation Regulation Of Endodeoxyribonuclease Activity Stress-induced Premature Senescence NAD-dependent Protein Lysine Deacetylase Activity Epigenetic Regulation Of Gene Expression Small GTPase Binding Ovulation From Ovarian Follicle Regulation Of Bile Acid Biosynthetic Process Pyrimidine Dimer Repair Regulation Of Transcription By Glucose Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Single Strand Break Repair Subtelomeric Heterochromatin Formation Chromatin Silencing Complex Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore UV-damage Excision Repair
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