PPBP and EFNA1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		PPBP	EFNA1
Description		pro-platelet basic protein	ephrin A1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Platelet Alpha Granule Lumen Tertiary Granule Lumen	Extracellular Region Plasma Membrane Membrane Side Of Membrane
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity Growth Factor Activity CXCR Chemokine Receptor Binding D-glucose Transmembrane Transporter Activity	Signaling Receptor Binding Protein Binding Ephrin Receptor Binding
	Biological Process	Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction Neutrophil Chemotaxis Killing Of Cells Of Another Organism Defense Response To Bacterium Positive Regulation Of Cell Division Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide D-glucose Transmembrane Transport	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Aortic Valve Morphogenesis Mitral Valve Morphogenesis Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Cell-cell Signaling Axon Guidance Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Epithelial To Mesenchymal Transition Notochord Formation Cell Migration Central Nervous System Neuron Differentiation Regulation Of Cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Negative Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis Ephrin Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Axonogenesis Protein Stabilization Negative Regulation Of Dendritic Spine Morphogenesis Regulation Of Biological Quality Negative Regulation Of Thymocyte Apoptotic Process Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
Pathways		Platelet degranulation Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs		Ethanesulfonic acid Copper
Diseases
GWAS		Metabolite levels ( 22916037)	Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Emotional recognition ( 31596458) Gamma glutamyl transferase levels ( 33339817) Inflammatory bowel disease ( 28067908) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514) Obesity-related traits ( 23251661) Prostate cancer ( 23535732) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 28714469) Urinary albumin excretion ( 30220432)
Interacting Genes		32 interacting genes: CCL13 CCL21 CCL26 CCL28 CCL5 CCL8 CELF1 CMTM6 COPG1 COPS7A COX17 CTSG CXCL10 CXCL11 CXCL12 CXCL14 CXCL6 CXCL9 CXCR1 CXCR2 DMWD EFNA1 MAPK6 MOB3B NDUFB11 NR4A1 PLEKHJ1 PMAIP1 RAB10 RPS27 SCFD1 STRN4	16 interacting genes: ADAM10 CD48 EEF1G EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 HUNK KAT5 PPBP XRCC6
Entrez ID		5473	1942
HPRD ID		07171	01858
Ensembl ID		ENSG00000163736	ENSG00000169242
Uniprot IDs		P02775	P20827
PDB IDs		1F9P 1NAP 1TVX	3CZU 3HEI 3MBW
Enriched GO Terms of Interacting Partners?		Chemokine Activity Cell Chemotaxis Leukocyte Chemotaxis Chemokine-mediated Signaling Pathway Chemotaxis Locomotion Antimicrobial Humoral Response Granulocyte Chemotaxis Leukocyte Migration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Myeloid Leukocyte Migration Granulocyte Migration Humoral Immune Response Cytokine Activity Killing Of Cells Of Another Organism Cell Migration Cytokine-mediated Signaling Pathway Mononuclear Cell Migration Cell Motility Cell Killing CXCR Chemokine Receptor Binding Inflammatory Response Eosinophil Chemotaxis Defense Response To Symbiont Eosinophil Migration Defense Response Defense Response To Other Organism Immune System Process Neutrophil Chemotaxis Immune Response CCR Chemokine Receptor Binding Chemokine Receptor Binding Neutrophil Migration Response To External Biotic Stimulus Response To Other Organism Cell-cell Signaling G Protein-coupled Receptor Signaling Pathway Signaling Cell Communication T Cell Chemotaxis Dendritic Cell Chemotaxis Negative Regulation Of Leukocyte Tethering Or Rolling CXCR3 Chemokine Receptor Binding Dendritic Cell Migration Lymphocyte Chemotaxis Neutrophil Activation Negative Regulation Of Cellular Extravasation T Cell Migration Positive Regulation Of T Cell Migration Extracellular Space	Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Signaling Pathway Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Protein Kinase Activity Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Guidance Axon Guidance Enzyme-linked Receptor Protein Signaling Pathway Dendrite ATP Binding Nucleotide Binding Transferase Activity Neuron Projection Development Regulation Of Cell Adhesion Signal Transduction Fasciculation Of Motor Neuron Axon Cell Surface Receptor Signaling Pathway Fasciculation Of Sensory Neuron Axon Plasma Membrane Bounded Cell Projection Organization Regulation Of GTPase Activity Growth Factor Binding Regulation Of Multicellular Organismal Development Nephric Duct Morphogenesis Cell Projection Organization Axon Guidance Receptor Activity Cell Adhesion Regulation Of Cell Junction Assembly Regulation Of Developmental Process Cell Migration Regulation Of Cellular Component Organization Regulation Of ERK1 And ERK2 Cascade Regulation Of Catalytic Activity Nervous System Development Regulation Of Synapse Organization Axonal Fasciculation Neuron Projection Fasciculation Retinal Ganglion Cell Axon Guidance Cell Recognition Chemotaxis System Development Cell Motility Central Nervous System Projection Neuron Axonogenesis Regulation Of MAPK Cascade Locomotion Regulation Of Postsynapse Organization Ephrin Receptor Binding
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