PPEF2 and MPHOSPH10

		PPEF2	MPHOSPH10
Description		protein phosphatase with EF-hand domain 2	M-phase phosphoprotein 10
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleus Cytoplasm Cytosol Cilium Cell Projection	Nucleus Nucleoplasm Chromosome Nucleolus Sno(s)RNA-containing Ribonucleoprotein Complex Small-subunit Processome Mpp10 Complex Ribonucleoprotein Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Iron Ion Binding Calcium Ion Binding Hydrolase Activity Manganese Ion Binding Protein Serine/threonine Kinase Inhibitor Activity Hsp70 Protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Metal Ion Binding Hsp90 Protein Binding	RNA Binding Protein Binding
	Biological Process	Protein Dephosphorylation Visual Perception Negative Regulation Of MAPK Cascade Detection Of Stimulus Involved In Sensory Perception Cellular Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Signaling Pathway	RNA Splicing, Via Transesterification Reactions RRNA Processing RNA Processing RNA Splicing Maturation Of SSU-rRNA Ribosome Biogenesis Ribosomal Small Subunit Biogenesis
Pathways			rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Hippocampal volume ( 29274321)	Coronary artery disease ( 29212778) Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: CALM1 CALM2 CALM3 MPHOSPH10	11 interacting genes: C2orf78 CSNK2A1 E2F1 GSTP1 IMP3 IMP4 NEUROG1 PCYOX1 PPEF2 PPP1CA RNF10
Entrez ID		5470	10199
HPRD ID		03771	10404
Ensembl ID		ENSG00000156194	ENSG00000124383
Uniprot IDs		O14830	O00566
PDB IDs			7MQ8 7MQ9 7MQA
Enriched GO Terms of Interacting Partners?		Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Titin Binding Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Calyx Of Held Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity Calcium Channel Complex Calcineurin-mediated Signaling Presynaptic Cytosol Myelin Sheath Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Transmembrane Transport Spindle Microtubule Presynaptic Endocytosis Substantia Nigra Development Calcium Channel Regulator Activity Sperm Midpiece Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Sarcomere Cell Cycle G2/M Phase Transition Neural Nucleus Development Negative Regulation Of Cation Transmembrane Transport Protein Serine/threonine Kinase Activator Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Voltage-gated Potassium Channel Complex Calcium-dependent Protein Binding Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Cytokinesis Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Vesicle-mediated Transport In Synapse Regulation Of Calcium-mediated Signaling Regulation Of Striated Muscle Contraction Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Sequestering Of Calcium Ion	Preribosome Mpp10 Complex Regulation Of Apoptotic Signaling Pathway SnoRNA Binding Protein Serine/threonine Kinase Inhibitor Activity Negative Regulation Of Apoptotic Signaling Pathway Double-strand Break Repair Via Nonhomologous End Joining Hsp90 Protein Binding Regulation Of Glial Cell Proliferation Dinitrosyl-iron Complex Binding S-nitrosoglutathione Binding Nitric Oxide Storage Prenylcysteine Oxidase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, Oxygen As Acceptor Prenylcysteine Catabolic Process Farnesylcysteine Lyase Activity RRNA Binding Maturation Of SSU-rRNA Regulation Of Translational Initiation Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Protein Kinase CK2 Complex RNA Metabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Phase Transition DNA Damage Checkpoint Signaling Forebrain Development Regulation Of Gliogenesis Regulation Of Fibroblast Proliferation Lens Fiber Cell Apoptotic Process TRAF2-GSTP1 Complex Glutathione Derivative Biosynthetic Process Cellular Response To Cell-matrix Adhesion Learned Vocalization Behavior Hard Palate Morphogenesis Mastication Vestibulocochlear Nerve Formation Positive Regulation Of Exit From Mitosis Negative Regulation Of Saliva Secretion Iron Ion Binding Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Prenylated Protein Catabolic Process Small-subunit Processome Ribosomal Small Subunit Biogenesis
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