UGT1A3 and AGAP1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)

		UGT1A3	AGAP1
Description		UDP glucuronosyltransferase family 1 member A3	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Nucleus Cytoplasm
	Molecular Function	Retinoic Acid Binding Glucuronosyltransferase Activity Enzyme Binding Protein Homodimerization Activity	GTPase Activity GTPase Activator Activity Protein Binding GTP Binding Phospholipid Binding Metal Ion Binding
	Biological Process	Estrogen Metabolic Process Bile Acid Secretion Retinoic Acid Metabolic Process Cellular Glucuronidation Flavonoid Glucuronidation Xenobiotic Glucuronidation Vitamin D3 Metabolic Process	Protein Transport Positive Regulation Of GTPase Activity
Pathways		Glucuronidation NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Drugs
Diseases
GWAS		Bilirubin levels ( 32084209) Hair greying ( 26926045) Liver disease biomarker ( 30576415) Low density lipoprotein cholesterol levels ( 32154731) Serum metabolite levels ( 23093944) Total bilirubin levels ( 29403010) Total bilirubin levels in HIV-1 infection ( 25884002)	Adult body size ( 32376654) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Craniofacial microsomia ( 26853712) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Menarche (age at onset) ( 23667675) Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 24 weeks) ( 28437668)
Interacting Genes			14 interacting genes: APP ARF1 ARF6 CDC42 GRB7 GUCY1A1 GUCY1B1 RAC1 RHOA RSPH14 SMN1 SRC TK1 ZNF534
Entrez ID		54659	116987
HPRD ID		07566	16359
Ensembl ID		ENSG00000243135	ENSG00000157985
Uniprot IDs		P35503 Q5DT01	B2RZG9 Q9UPQ3 X5D293
PDB IDs
Enriched GO Terms of Interacting Partners?
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