AGAP1 and DNAJB3

		AGAP1	DNAJB3
Description		ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	DnaJ heat shock protein family (Hsp40) member B3
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GO Annotations	Cellular Component	Cytoplasm Postsynaptic Endosome	Cytoplasm
	Molecular Function	Nucleotide Binding GTPase Activity GTPase Activator Activity Protein Binding GTP Binding Phospholipid Binding Zinc Ion Binding Metal Ion Binding	Hsp70 Protein Binding Unfolded Protein Binding Protein-folding Chaperone Binding
	Biological Process	Protein Transport Regulation Of Modification Of Postsynaptic Structure	Negative Regulation Of Inclusion Body Assembly
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Anterior thalamic nuclei volume ( 34006833) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Craniofacial microsomia ( 26853712) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Menarche (age at onset) ( 23667675) Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 24 weeks) ( 28437668)	Hair greying ( 26926045) Total bilirubin levels in HIV-1 infection ( 25884002)
Interacting Genes		23 interacting genes: ALPI APP ARF1 ARF6 CDC42 DNAJB3 DYRK1A GRB7 GUCY1A1 GUCY1B1 ITM2C RAC1 RHOA RSPH14 SLC19A3 SMN1 SP110 SRC TK1 UGT1A1 UGT1A3 WEE2-AS1 ZNF534	2 interacting genes: AGAP1 EWSR1
Entrez ID		116987	414061
HPRD ID		16359	13638
Ensembl ID		ENSG00000157985	ENSG00000293135
Uniprot IDs		B2RZG9 E7EUN2 Q9UPQ3	Q8WWF6
PDB IDs		7EB6	2EJ7
Enriched GO Terms of Interacting Partners?		Regulation Of Supramolecular Fiber Organization GTP Binding Membrane Invagination Thioesterase Binding Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Regulation Of Endocytosis G Protein Activity Regulation Of Cell-substrate Junction Organization Guanylate Cyclase Complex, Soluble Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Establishment Of Epithelial Cell Polarity Positive Regulation Of Locomotion Postsynapse Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Lamellipodium Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Protein-containing Complex Assembly Regulation Of Cell Projection Organization Regulation Of Cell Junction Assembly Neuron Projection Organization Regulation Of Receptor-mediated Endocytosis Cell Junction Organization Regulation Of Actin Filament Organization Positive Regulation Of Cytokinesis Negative Regulation Of Cellular Component Organization Substrate Adhesion-dependent Cell Spreading Nucleotide Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Synapse Organization Non-canonical Wnt Signaling Pathway Regulation Of Lamellipodium Organization Signaling Receptor Activator Activity Positive Regulation Of Stress Fiber Assembly Guanylate Cyclase Activity Regulation Of Cytoskeleton Organization GTPase Activity Establishment Or Maintenance Of Cell Polarity Circulatory System Process Nitric Oxide-cGMP-mediated Signaling Regulation Of Vesicle-mediated Transport Regulation Of Actin Cytoskeleton Organization Glutamatergic Synapse Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Podosome Assembly Flavonoid Metabolic Process Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Focal Adhesion Assembly	Postsynaptic Endosome Regulation Of Modification Of Synaptic Structure Regulation Of Modification Of Postsynaptic Structure
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