TRMT13 and TMED5

		TRMT13	TMED5
Description		tRNA methyltransferase 13	transmembrane p24 trafficking protein 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Membrane COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum Exit Site
	Molecular Function	Methyltransferase Activity TRNA Methyltransferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding TRNA 2'-O-methyltransferase Activity	Protein Binding
	Biological Process	TRNA Processing TRNA Methylation Methylation	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Golgi Ribbon Formation
Pathways		tRNA modification in the nucleus and cytosol	WNT ligand biogenesis and trafficking
Drugs
Diseases
GWAS			High density lipoprotein cholesterol levels ( 29403010)
Interacting Genes		1 interacting genes: TMED5	7 interacting genes: CXCL9 DCTN1 KIF21B PCSK9 PRMT6 TMEM132D TRMT13
Entrez ID		54482	50999
HPRD ID		07659	13028
Ensembl ID		ENSG00000122435	ENSG00000117500
Uniprot IDs		B4DGS0 B4DIY2 B4DQS9 Q9NUP7	M0R072 Q9Y3A6
PDB IDs
Enriched GO Terms of Interacting Partners?		Golgi Ribbon Formation Cis-Golgi Network COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum Exit Site Endoplasmic Reticulum-Golgi Intermediate Compartment Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Golgi Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport	Cell Cortex Region Positive Regulation Of Neuromuscular Junction Development TRNA 2'-O-methyltransferase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Histone Arginine N-methyltransferase Activity Negative Regulation Of Sodium Ion Import Across Plasma Membrane Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Intracellular Cholesterol Transport Negative Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Low-density Lipoprotein Receptor Particle Metabolic Process Extrinsic Component Of External Side Of Plasma Membrane PCSK9-AnxA2 Complex Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process PCSK9-LDLR Complex CXCR3 Chemokine Receptor Binding Methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity Very-low-density Lipoprotein Particle Binding Negative Regulation Of Receptor Recycling Very-low-density Lipoprotein Particle Receptor Binding Apolipoprotein Receptor Binding Positive Regulation Of Microtubule Nucleation Centriolar Subdistal Appendage Ventral Spinal Cord Development TRNA Methyltransferase Activity Methylation Protein-arginine N-methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Sodium Channel Inhibitor Activity Positive Regulation Of Receptor Catabolic Process Regulation Of Intracellular Cholesterol Transport Regulation Of Intracellular Lipid Transport Signaling Receptor Inhibitor Activity Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Sodium Ion Transmembrane Transport
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