TMED5 and TRMT13

		TMED5	TRMT13
Description		transmembrane p24 trafficking protein 5	tRNA methyltransferase 13
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Membrane COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum Exit Site
	Molecular Function	Protein Binding	Methyltransferase Activity TRNA Methyltransferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding TRNA 2'-O-methyltransferase Activity
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Golgi Ribbon Formation	TRNA Processing TRNA Methylation Methylation
Pathways		WNT ligand biogenesis and trafficking	tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		High density lipoprotein cholesterol levels ( 29403010)
Interacting Genes		7 interacting genes: CXCL9 DCTN1 KIF21B PCSK9 PRMT6 TMEM132D TRMT13	1 interacting genes: TMED5
Entrez ID		50999	54482
HPRD ID		13028	07659
Ensembl ID		ENSG00000117500	ENSG00000122435
Uniprot IDs		M0R072 Q9Y3A6	B4DGS0 B4DIY2 B4DQS9 Q9NUP7
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Cortex Region Positive Regulation Of Neuromuscular Junction Development TRNA 2'-O-methyltransferase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Histone Arginine N-methyltransferase Activity Negative Regulation Of Sodium Ion Import Across Plasma Membrane Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Intracellular Cholesterol Transport Negative Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Low-density Lipoprotein Receptor Particle Metabolic Process Extrinsic Component Of External Side Of Plasma Membrane PCSK9-AnxA2 Complex Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process PCSK9-LDLR Complex CXCR3 Chemokine Receptor Binding Methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity Very-low-density Lipoprotein Particle Binding Negative Regulation Of Receptor Recycling Very-low-density Lipoprotein Particle Receptor Binding Apolipoprotein Receptor Binding Positive Regulation Of Microtubule Nucleation Centriolar Subdistal Appendage Ventral Spinal Cord Development TRNA Methyltransferase Activity Methylation Protein-arginine N-methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Sodium Channel Inhibitor Activity Positive Regulation Of Receptor Catabolic Process Regulation Of Intracellular Cholesterol Transport Regulation Of Intracellular Lipid Transport Signaling Receptor Inhibitor Activity Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Sodium Ion Transmembrane Transport	Golgi Ribbon Formation Cis-Golgi Network COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum Exit Site Endoplasmic Reticulum-Golgi Intermediate Compartment Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Golgi Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
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