GUK1

Description		guanylate kinase 1
Image
GO Annotations	Cellular Component	Photoreceptor Inner Segment Cytoplasm Mitochondrion Cytosol
	Molecular Function	Nucleotide Binding GMP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Purine Nucleotide Metabolic Process DGDP Biosynthetic Process Xenobiotic Metabolic Process Nucleobase-containing Small Molecule Interconversion GDP-mannose Metabolic Process Glycoprotein Transport GMP Metabolic Process DGMP Metabolic Process DATP Metabolic Process GDP Biosynthetic Process
Pathways		Interconversion of nucleotide di- and triphosphates Azathioprine ADME
Drugs		Guanosine-5'-Monophosphate
Diseases
GWAS		Coronary artery disease ( 29212778)
Novel Interacting Genes		5 novel interacting genes: HNRNPD LCOR NLGN3 STAG1 VHL
Interacting Genes		5 interacting genes: HNRNPD LCOR NLGN3 STAG1 VHL
Entrez ID		2987
HPRD ID		00755
Ensembl ID		ENSG00000143774
Uniprot IDs		Q16774 Q6IBG8
PDB IDs		6NUI 8PTS
Enriched GO Terms of Interacting Partners?		Cellular Response To Estradiol Stimulus Hepatocyte Dedifferentiation Cellular Response To Putrescine Response To Estradiol Histone Deacetylase Binding Circadian Regulation Of Translation Rhythmic Synaptic Transmission Symmetric, GABA-ergic, Inhibitory Synapse Response To Rapamycin Positive Regulation Of Telomere Capping Cell Dedifferentiation MCRD-mediated MRNA Stability Complex Response To Sodium Phosphate Minor Groove Of Adenine-thymine-rich DNA Binding Transcription Elongation Factor Activity Establishment Of Mitotic Sister Chromatid Cohesion Cohesin Complex Establishment Of Sister Chromatid Cohesion Mitotic Cohesin Complex Asymmetric, Glutamatergic, Excitatory Synapse Inhibitory Postsynaptic Potential Positive Regulation Of Glutamate Receptor Signaling Pathway Postsynaptic Membrane Assembly Postsynaptic Membrane Organization Presynaptic Membrane Assembly Neuron To Neuron Synapse Presynaptic Membrane Organization CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of Glutamate Receptor Signaling Pathway Neurexin Family Protein Binding Presynapse Assembly Cellular Response To Nitric Oxide Negative Regulation Of Catabolic Process Regulation Of Telomere Capping Regulation Of Respiratory System Process Neuron Cell-cell Adhesion Histone Methyltransferase Binding Negative Regulation Of RNA Metabolic Process Cellular Response To Reactive Nitrogen Species Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Cytoplasmic Translation 3'-UTR-mediated MRNA Destabilization Response To Nitric Oxide Response To Ether Regulation Of Cellular Response To Hypoxia Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
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