POLE and MMP17

		POLE	MMP17
Description		DNA polymerase epsilon, catalytic subunit	matrix metallopeptidase 17
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Epsilon DNA Polymerase Complex	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Matrix Side Of Membrane
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Single-stranded DNA 3'-5' DNA Exonuclease Activity Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity DNA Polymerase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Metalloendopeptidase Activity Enzyme Activator Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair DNA Replication DNA-templated DNA Replication Leading Strand Elongation DNA Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Gap Filling DNA Damage Response DNA Replication Proofreading Embryonic Organ Development DNA Biosynthetic Process	Kidney Development Proteolysis Extracellular Matrix Organization Collagen Catabolic Process Drinking Behavior
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Activation of Matrix Metalloproteinases
Drugs		Cladribine	Marimastat
Diseases
GWAS		Body mass index ( 26426971) Metabolite levels ( 23823483) Urate levels in overweight individuals ( 25811787)	Body mass index ( 26426971) Migraine ( 22683712) Psychosis proneness (perceptual aberration scale) ( 28525603)
Interacting Genes		20 interacting genes: ABHD16A CFTR CLSPN EIF2B1 GINS4 MDM2 MMP17 NOS1 PCNA POLA1 POLD4 POLE4 RAD17 RAN SCARB1 TOPBP1 ULK1 VSIG4 WHR1 XRCC5	5 interacting genes: HSP90B1 LRP1 MMP2 POLE TNF
Entrez ID		5426	4326
HPRD ID		07177	03793
Ensembl ID		ENSG00000177084	ENSG00000198598
Uniprot IDs		Q07864	Q9ULZ9
PDB IDs		5VBN 7PFO 7PLO 9B8S 9B8T 9F6D 9F6E 9F6F 9F6I 9F6J 9F6K 9F6L
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Repair Response To Stress DNA Damage Response Cellular Response To Stress DNA Biosynthetic Process Mitotic DNA Replication Checkpoint Signaling DNA-templated DNA Replication DNA Replication DNA Replication Checkpoint Signaling DNA-directed DNA Polymerase Activity Nucleic Acid Metabolic Process Leading Strand Elongation DNA Synthesis Involved In DNA Repair Macromolecule Metabolic Process Signal Transduction In Response To DNA Damage Male Germ Cell Nucleus Mitotic G2/M Transition Checkpoint Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition DNA Strand Elongation Involved In DNA Replication Double-strand Break Repair Protein-containing Complex Chromatin-protein Adaptor Activity DNA Damage Checkpoint Signaling Response To Lipid DNA Strand Elongation Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Localization To Chromosome Regulation Of Cell Cycle G2/M Phase Transition Nucleoplasm Protein Localization To Site Of Double-strand Break DNA Replication Initiation Cellular Response To Gamma Radiation Recycling Endosome Regulation Of Mitotic Cell Cycle Phase Transition Recombinational Repair Response To Hormone Response To Ionizing Radiation Chromosome Organization Protein-containing Complex Binding Protein Localization To Organelle Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Sphingolipid Mediated Signaling Pathway High-density Lipoprotein Particle Receptor Activity	Response To Amyloid-beta Regulation Of Amyloid-beta Clearance Astrocyte Activation Vascular Process In Circulatory System Circulatory System Process Cellular Response To Oxygen-containing Compound Response To Hypoxia Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Response To Nicotine Response To Oxygen Levels Response To Decreased Oxygen Levels Cellular Response To Amyloid-beta Positive Regulation Of Transcytosis Positive Regulation Of Protein Localization To Cell Periphery Alpha-2 Macroglobulin Receptor Activity Positive Regulation Of Protein Localization To Membrane Apolipoprotein Receptor Activity Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Amino Acid Stimulus Response To Activity Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis Cellular Response To Stress Response To Retinoic Acid Positive Regulation Of Reverse Cholesterol Transport Regulation Of Protein Localization To Plasma Membrane Regulation Of Transcytosis Response To Amino Acid Regeneration Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of L-glutamate Import Across Plasma Membrane Positive Regulation Of Fractalkine Production Positive Regulation Of Blood Microparticle Formation Response To Gold Nanoparticle Positive Regulation Of Vitamin D Biosynthetic Process Actin Rod Assembly Regulation Of Protein Localization To Cell Periphery Cell Activation Involved In Immune Response Lipoprotein Particle Receptor Binding Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Apoptotic Signaling Pathway Blood Vessel Diameter Maintenance Regulation Of Tube Size
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