CLIC6 and ALDH5A1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		CLIC6	ALDH5A1
Description		chloride intracellular channel 6	aldehyde dehydrogenase 5 family member A1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Monoatomic Ion Channel Complex Chloride Channel Complex Extracellular Exosome	Mitochondrion Mitochondrial Matrix Synapse
	Molecular Function	Chloride Channel Activity Oxidoreductase Activity D2 Dopamine Receptor Binding D3 Dopamine Receptor Binding D4 Dopamine Receptor Binding	Succinate-semialdehyde Dehydrogenase (NAD+) Activity Succinate-semialdehyde Dehydrogenase [NAD(P)+] Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Identical Protein Binding
	Biological Process	Monoatomic Ion Transport Chloride Transport Monoatomic Ion Transmembrane Transport Chloride Transmembrane Transport	Succinate Metabolic Process Glutamate Metabolic Process Central Nervous System Development Gamma-aminobutyric Acid Metabolic Process Gamma-aminobutyric Acid Catabolic Process Post-embryonic Development Carboxylic Acid Metabolic Process Synaptic Transmission, GABAergic
Pathways			Degradation of GABA
Drugs			Succinic acid NADH Valproic acid Chlormerodrin
Diseases			Succinic semialdehyde dehydrogenase (SSADH) deficiency; 4-Hydroxybutyric aciduria (4-HBA)
GWAS		Asthma ( 31959851) Breast cancer ( 31757997) Epigenetic age acceleration in alcohol use disorder ( 31466081) Hippocampal volume ( 29274321) Psoriasis ( 25903422) Waist-to-hip ratio adjusted for BMI ( 28552196)	Liver enzyme levels (alkaline phosphatase) ( 22001757)
Interacting Genes		28 interacting genes: ACTB ALDH5A1 ARG2 ATRX CLIC4 DRD2 DRD3 DRD4 EEF1A1 FCGR1A GFPT2 HUWE1 LGI1 MYO1E NFE2L2 NISCH OXR1 PGK1 PKM PPRC1 SMIM11 TAF12 TUBGCP5 UBE4A ZNF18 ZNF224 ZNF234 ZNF439	5 interacting genes: ABAT ARF6 CLIC6 MAGEA11 OGT
Entrez ID		54102	7915
HPRD ID		10836	08361
Ensembl ID		ENSG00000159212	ENSG00000112294
Uniprot IDs		Q96NY7	P51649 X5D299 X5DQN2
PDB IDs			2W8N 2W8O 2W8P 2W8Q 2W8R
Enriched GO Terms of Interacting Partners?		Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Dopamine Neurotransmitter Receptor Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Phospholipase C-activating Dopamine Receptor Signaling Pathway Response To Histamine Synaptic Transmission, Dopaminergic Behavioral Response To Cocaine Regulation Of Neurotransmitter Uptake Arachidonate Secretion G Protein-coupled Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Dopamine Binding Positive Regulation Of Neurotransmitter Uptake Long-chain Fatty Acid Transport Negative Regulation Of Synaptic Transmission, Glutamatergic Adult Behavior Behavioral Response To Ethanol Regulation Of Dopamine Receptor Signaling Pathway Circadian Regulation Of Gene Expression Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Protein Secretion Prepulse Inhibition G Protein-coupled Receptor Internalization Locomotory Behavior Regulation Of Amine Transport Adult Locomotory Behavior Negative Regulation Of Cytosolic Calcium Ion Concentration Ubiquitin-ubiquitin Ligase Activity Response To Morphine Fatty Acid Transport Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cellular Response To Oxidative Stress Canonical Glycolysis Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate Regulation Of Cellular Response To Hypoxia Regulation Of Dopamine Secretion Rhythmic Process Acid Secretion Secretory Granule Lumen Glucose Catabolic Process Regulation Of Transcription By RNA Polymerase II Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Protein Transport Dopamine Metabolic Process Ficolin-1-rich Granule Lumen Regulation Of Response To Oxidative Stress Response To Amphetamine Regulation Of Cellular Response To Stress	(S)-3-amino-2-methylpropionate Transaminase Activity Succinate-semialdehyde Dehydrogenase Binding 4-aminobutyrate Transaminase Complex 4-aminobutyrate:2-oxoglutarate Transaminase Activity Regulation Of Rac Protein Signal Transduction Erythrocyte Apoptotic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly D4 Dopamine Receptor Binding Positive Regulation Of Prolactin Secretion Gamma-aminobutyric Acid Catabolic Process Positive Regulation Of Aspartate Secretion Copulation Negative Regulation Of Gamma-aminobutyric Acid Secretion D3 Dopamine Receptor Binding Positive Regulation Of Protein Secretion Regulation Of Protein Localization To Cell Periphery Regulation Of Synapse Assembly Protein Localization To Cleavage Furrow Protein O-acetylglucosaminyltransferase Activity D2 Dopamine Receptor Binding Positive Regulation Of Dopamine Metabolic Process Gamma-aminobutyric Acid Biosynthetic Process Modulation Of Inhibitory Postsynaptic Potential Negative Regulation Of Dopamine Secretion Positive Regulation Of Uterine Smooth Muscle Contraction Regulation Of Protein Localization Positive Regulation Of Protein Transport Positive Regulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Mitotic Cytokinetic Process Cellular Response To Diacyl Bacterial Lipopeptide Negative Regulation Of Dendrite Development Regulation Of Protein Localization To Membrane Maintenance Of Postsynaptic Density Structure Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Protein Secretion Gamma-aminobutyric Acid Metabolic Process Regulation Of Cell Junction Assembly Positive Regulation Of Focal Adhesion Disassembly Regulation Of Uterine Smooth Muscle Contraction Regulation Of Transcription By Glucose Positive Regulation Of Heat Generation Positive Regulation Of Secretion By Cell Thioesterase Binding Positive Regulation Of Keratinocyte Migration Maintenance Of Postsynaptic Specialization Structure
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