CLIC6 and SMIM11

		CLIC6	SMIM11
Description		chloride intracellular channel 6	small integral membrane protein 11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Monoatomic Ion Channel Complex Chloride Channel Complex Extracellular Exosome	Membrane
	Molecular Function	Chloride Channel Activity Oxidoreductase Activity D2 Dopamine Receptor Binding D3 Dopamine Receptor Binding D4 Dopamine Receptor Binding	Protein Binding
	Biological Process	Monoatomic Ion Transport Chloride Transport Monoatomic Ion Transmembrane Transport Chloride Transmembrane Transport
Pathways
Drugs
Diseases
GWAS		Asthma ( 31959851) Breast cancer ( 31757997) Epigenetic age acceleration in alcohol use disorder ( 31466081) Hippocampal volume ( 29274321) Psoriasis ( 25903422) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		28 interacting genes: ACTB ALDH5A1 ARG2 ATRX CLIC4 DRD2 DRD3 DRD4 EEF1A1 FCGR1A GFPT2 HUWE1 LGI1 MYO1E NFE2L2 NISCH OXR1 PGK1 PKM PPRC1 SMIM11 TAF12 TUBGCP5 UBE4A ZNF18 ZNF224 ZNF234 ZNF439	6 interacting genes: APP ASPH CERS4 CLIC6 LMNA UBQLN2
Entrez ID		54102	54065
HPRD ID		10836	10751
Ensembl ID		ENSG00000159212	ENSG00000205670
Uniprot IDs		Q96NY7	P58511
PDB IDs
Enriched GO Terms of Interacting Partners?		Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Dopamine Neurotransmitter Receptor Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Phospholipase C-activating Dopamine Receptor Signaling Pathway Response To Histamine Synaptic Transmission, Dopaminergic Behavioral Response To Cocaine Regulation Of Neurotransmitter Uptake Arachidonate Secretion G Protein-coupled Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Dopamine Binding Positive Regulation Of Neurotransmitter Uptake Long-chain Fatty Acid Transport Negative Regulation Of Synaptic Transmission, Glutamatergic Adult Behavior Behavioral Response To Ethanol Regulation Of Dopamine Receptor Signaling Pathway Circadian Regulation Of Gene Expression Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Protein Secretion Prepulse Inhibition G Protein-coupled Receptor Internalization Locomotory Behavior Regulation Of Amine Transport Adult Locomotory Behavior Negative Regulation Of Cytosolic Calcium Ion Concentration Ubiquitin-ubiquitin Ligase Activity Response To Morphine Fatty Acid Transport Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cellular Response To Oxidative Stress Canonical Glycolysis Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate Regulation Of Cellular Response To Hypoxia Regulation Of Dopamine Secretion Rhythmic Process Acid Secretion Secretory Granule Lumen Glucose Catabolic Process Regulation Of Transcription By RNA Polymerase II Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Protein Transport Dopamine Metabolic Process Ficolin-1-rich Granule Lumen Regulation Of Response To Oxidative Stress Response To Amphetamine Regulation Of Cellular Response To Stress	Positive Regulation Of Proteolysis Positive Regulation Of Response To Endoplasmic Reticulum Stress Acetylcholine Receptor Activator Activity Negative Regulation Of Cell Population Proliferation Amyloid-beta Complex PTB Domain Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Purine-containing Compound Growth Cone Lamellipodium Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Calcium Ion Calcium-mediated Signaling Amylin Binding Regulation Of Proteolysis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Receptor-mediated Endocytosis Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of System Process Lipoprotein Particle Regulation Of Protein Localization To Nucleus Regulation Of Receptor Internalization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Peptidyl-aspartic Acid 3-dioxygenase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of G Protein-coupled Receptor Internalization D2 Dopamine Receptor Binding D4 Dopamine Receptor Binding D3 Dopamine Receptor Binding Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding
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