PNLIP and CLPS

Number of citations of the paper that reports this interaction (PubMedID 8479519)
0

Data Source:
HPRD (in vitro)

		PNLIP	CLPS
Description		pancreatic lipase	colipase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region
	Molecular Function	Lipoprotein Lipase Activity Triacylglycerol Lipase Activity Phospholipase A1 Activity Lipase Activity Hydrolase Activity Metal Ion Binding All-trans-retinyl-palmitate Hydrolase, All-trans-retinol Forming Activity Retinyl-palmitate Esterase Activity Carboxylic Ester Hydrolase Activity	Enzyme Activator Activity Lipase Binding
	Biological Process	Retinoid Metabolic Process Lipid Metabolic Process Fatty Acid Biosynthetic Process Lipid Catabolic Process Triglyceride Catabolic Process Intestinal Cholesterol Absorption High-density Lipoprotein Particle Remodeling Retinol Metabolic Process Cholesterol Homeostasis Positive Regulation Of Triglyceride Lipase Activity	Retinoid Metabolic Process Lipid Metabolic Process Digestion Response To Bacterium Lipid Catabolic Process Response To Food
Pathways		Digestion of dietary lipid Retinoid metabolism and transport Developmental Lineage of Pancreatic Acinar Cells	Digestion of dietary lipid Retinoid metabolism and transport
Drugs		Orlistat B-nonylglucoside (Hydroxyethyloxy)Tri(Ethyloxy)Octane Cetilistat METHOXYUNDECYLPHOSPHINIC ACID Chlortetracycline	B-nonylglucoside (Hydroxyethyloxy)Tri(Ethyloxy)Octane METHOXYUNDECYLPHOSPHINIC ACID
Diseases
GWAS		Anger ( 24489884) Body mass index ( 26426971)	Blood protein levels ( 30072576)
Interacting Genes		2 interacting genes: CLPS YWHAE	4 interacting genes: GLP1R LIPF PNLIP PNLIPRP2
Entrez ID		5406	1208
HPRD ID		02005	00356
Ensembl ID		ENSG00000175535	ENSG00000137392
Uniprot IDs		P16233	A0A087WZW1 A0A087X0Q7 P04118
PDB IDs		1GPL 1LPA 1LPB 1N8S
Enriched GO Terms of Interacting Partners?		Regulation Of Heart Rate By Hormone Regulation Of Heart Rate By Chemical Signal Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Phosphoserine Residue Binding Positive Regulation Of Toll-like Receptor Signaling Pathway Digestion Response To Food Lipase Binding Regulation Of Hippo Signaling Membrane Repolarization During Action Potential Calcium Channel Regulator Activity Cell Surface Toll-like Receptor Signaling Pathway Potassium Channel Regulator Activity Protein Localization To Endoplasmic Reticulum Regulation Of Protein Export From Nucleus Hippo Signaling MHC Class II Protein Complex Binding Protein Sequestering Activity Substantia Nigra Development Regulation Of Membrane Repolarization Protein K11-linked Ubiquitination Regulation Of Heart Rate By Cardiac Conduction Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Calcium Ion Transmembrane Transport Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Export From Nucleus Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Hippo Signaling Phosphoprotein Binding Molecular Function Inhibitor Activity Calcium Channel Inhibitor Activity Cardiac Conduction Intracellular Potassium Ion Homeostasis Potassium Ion Homeostasis Protein Phosphatase Inhibitor Activity Negative Regulation Of Calcium Ion Transport Cellular Response To Heat Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Neural Nucleus Development Positive Regulation Of Nucleocytoplasmic Transport Golgi To Plasma Membrane Transport Negative Regulation Of Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Hippocampus Development Innate Immune Response Activating Cell Surface Receptor Signaling Pathway	Triacylglycerol Lipase Activity Lipase Activity Carboxylic Ester Hydrolase Activity Triglyceride Metabolic Process Acylglycerol Metabolic Process Neutral Lipid Metabolic Process Lipoprotein Lipase Activity Triglyceride Catabolic Process Phospholipase A1 Activity High-density Lipoprotein Particle Remodeling Acylglycerol Catabolic Process Lipid Catabolic Process Glycerolipid Metabolic Process Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Sterol Homeostasis Cholesterol Homeostasis Glucagon-like Peptide 1 Receptor Activity Positive Regulation Of Triglyceride Lipase Activity Galactolipase Activity Fatty Acid Biosynthetic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Galactolipid Catabolic Process Lipid Homeostasis Glucagon Receptor Activity All-trans-retinyl-palmitate Hydrolase, All-trans-retinol Forming Activity Malate Dehydrogenase Activity Lipid Metabolic Process Lipid Digestion Response To Psychosocial Stress Carboxylic Acid Biosynthetic Process Retinyl-palmitate Esterase Activity Post-translational Protein Targeting To Membrane, Translocation Fatty Acid Metabolic Process Positive Regulation Of Lipase Activity Malate Metabolic Process Positive Regulation Of Catalytic Activity Small Molecule Metabolic Process Intestinal Cholesterol Absorption Cellular Response To Glucagon Stimulus Monoacylglycerol Lipase Activity Phosphatidylcholine Catabolic Process Activation Of Adenylate Cyclase Activity Intestinal Lipid Absorption Hydrolase Activity Small Molecule Biosynthetic Process Zymogen Granule Membrane Positive Regulation Of Adenylate Cyclase Activity Monocarboxylic Acid Metabolic Process
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