MCHR1

Description		melanin concentrating hormone receptor 1
Image
GO Annotations	Cellular Component	Plasma Membrane Cilium Membrane Neuron Projection Ciliary Membrane Non-motile Cilium
	Molecular Function	G Protein-coupled Receptor Activity Signaling Receptor Binding Neuropeptide Receptor Activity Melanin-concentrating Hormone Receptor Activity Hormone Binding Neuropeptide Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Feeding Behavior Positive Regulation Of Calcium Ion Transport
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events BBSome-mediated cargo-targeting to cilium
Drugs		Haloperidol
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body mass index ( 26426971) Feeling worry ( 29500382) Large artery stroke ( 28265093) Neurociticism ( 29500382) Refractive error ( 32231278) Schizophrenia ( 28991256)
Novel Interacting Genes		4 novel interacting genes: EP300 HUNK PMCH ZMYND19
Interacting Genes		4 interacting genes: EP300 HUNK PMCH ZMYND19
Entrez ID		2847
HPRD ID		11874
Ensembl ID		ENSG00000128285
Uniprot IDs		Q99705
PDB IDs		8WSS 8WWH 8WWI 8WWJ 8WWK 8WWL 8WWM 8WWN 8YNT
Enriched GO Terms of Interacting Partners?		Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Type 1 Melanin-concentrating Hormone Receptor Binding Melanin-concentrating Hormone Activity Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Negative Regulation Of Synaptic Transmission, Dopaminergic N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Peptide Lactyltransferase (CoA-dependent) Activity Negative Regulation Of Protein Oligomerization L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Positive Regulation Of TORC2 Signaling Positive Regulation Of T-helper 17 Cell Lineage Commitment Regulation Of Tubulin Deacetylation Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Regulation Of Synaptic Transmission, Dopaminergic Pre-mRNA Intronic Binding Positive Regulation Of T-helper 17 Cell Differentiation Regulation Of Protein Deacetylation Cellular Response To L-leucine N-terminal Protein Amino Acid Acetylation Internal Protein Amino Acid Acetylation Peptidyl-lysine Acetylation Regulation Of TORC2 Signaling Positive Regulation Of Cell Fate Commitment T-helper 17 Cell Lineage Commitment STAT Family Protein Binding Histone H4 Acetyltransferase Activity TORC2 Signaling Regulation Of Cellular Response To Heat Response To L-leucine Negative Regulation Of Gluconeogenesis Host-mediated Activation Of Viral Transcription Tricarboxylic Acid Metabolic Process T-helper Cell Lineage Commitment Acetyltransferase Activity
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