PLD2 and RPTOR

Number of citations of the paper that reports this interaction (PubMedID 16837165)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		PLD2	RPTOR
Description		phospholipase D2	regulatory associated protein of MTOR complex 1
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Membrane Cytoplasmic Vesicle Brush Border Membrane Presynapse	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Cytoplasmic Stress Granule Membrane Dendrite TORC1 Complex Neuronal Cell Body Serine/threonine Protein Kinase Complex
	Molecular Function	Catalytic Activity Phospholipase D Activity Protein Binding Hydrolase Activity Phosphatidylinositol Binding	Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Kinase Activator Activity Protein-macromolecule Adaptor Activity Small GTPase Binding Protein-containing Complex Binding 14-3-3 Protein Binding Enzyme-substrate Adaptor Activity
	Biological Process	G Protein-coupled Receptor Internalization Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Receptor-mediated Endocytosis Cytoskeleton Organization Small GTPase-mediated Signal Transduction Phospholipid Catabolic Process Lipid Catabolic Process Intracellular Signal Transduction Synaptic Vesicle Recycling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Vesicle-mediated Transport	Autophagosome Assembly Regulation Of Cell Growth Positive Regulation Of Endothelial Cell Proliferation Cytoplasmic Translation DNA Damage Response Regulation Of Cell Size Cellular Response To Starvation Response To Xenobiotic Stimulus Regulation Of Autophagy Negative Regulation Of Autophagy Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Social Behavior TORC1 Signaling Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of Transcription By RNA Polymerase III Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Positive Regulation Of Lipid Biosynthetic Process Protein Localization To Lysosome Regulation Of Biological Quality Cellular Response To Amino Acid Stimulus Cellular Response To L-leucine Cellular Response To Glucose Stimulus Cellular Response To Hypoxia Cellular Response To Osmotic Stress Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Odontoblast Differentiation Positive Regulation Of TORC1 Signaling Positive Regulation Of Pentose-phosphate Shunt
Pathways		Synthesis of PG Synthesis of PA Role of phospholipids in phagocytosis RAC1 GTPase cycle RAC2 GTPase cycle	Macroautophagy MTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs		Choline Choline salicylate
Diseases
GWAS		Sphingolipid levels ( 22359512) Systemic lupus erythematosus ( 26502338)	Adult body size ( 32376654) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Body mass index ( 25673413 28892062) Body size at age 10 ( 32376654) Hypertension ( 30487518) Mean arterial pressure ( 30487518) NASH resolution in nonalcoholic steatohepatitis ( 31832568) Nicotine dependence symptom count ( 25555482) Obesity ( 23563607) Pulse pressure ( 29403010 30487518) Systolic blood pressure ( 30487518)
Interacting Genes		30 interacting genes: ACTB ACTN1 ALDOA ALDOC AMPH AQP3 ARF1 BIN1 CAV1 CSK DPYSL2 EGFR FYN GAPDH GM2A HIF1A LCK MTDH MTOR OPRM1 PEA15 PIP5K1A PLCG1 PRKCA PRKCD RPTOR SRC STXBP1 TIMM10B VHL	35 interacting genes: BAHCC1 CBX8 CCDC40 CILK1 DCXR DUXAP9 EIF4EBP1 EIF4EBP2 GTF3C5 IRS1 IRS2 LINC00839 MAPK1 MAPK3 MARK4 MLST8 MTOR NLK NRBF2 OGT PLD2 PPDPF PRKAA1 PRKAA2 RAP1B RHEB RNF213 RPS6KA1 RPS6KA3 RPS6KB1 RRAGB TNRC6C USP36 WDR45B WIPI2
Entrez ID		5338	57521
HPRD ID		03857	06184
Ensembl ID		ENSG00000129219	ENSG00000141564
Uniprot IDs		O14939	Q8N122
PDB IDs		6OHM 6OHO 6OHP 6OHQ 6OHS 7SVP	5H64 6BCU 6BCX 6SB0 6SB2 6U62 7OWG 7PEA 7PEB 7PEC 7UX2 7UXC 7UXH 8ERA 8RCH 8RCK 8RCN 9F42 9F43 9F44 9F45
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Regulation Of Apoptotic Process T Cell Costimulation Protein Tyrosine Kinase Activity Phospholipase Activator Activity Positive Regulation Of Immune System Process Cytosol Negative Regulation Of Apoptotic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Negative Regulation Of Programmed Cell Death Positive Regulation Of Multicellular Organismal Process Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Phospholipase Binding Cell-cell Junction Regulation Of Developmental Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Glycolytic Process Plasma Membrane Regulation Of Transport Regulation Of Immune System Process Positive Regulation Of Signal Transduction Regulation Of Cell-cell Adhesion Regulation Of Multicellular Organismal Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Positive Regulation Of T Cell Activation Cytoplasm Cellular Response To Oxygen Levels Regulation Of Cell Communication Regulation Of Signaling Enzyme Binding Cellular Response To Chemical Stress Fc-gamma Receptor Signaling Pathway Identical Protein Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of ATP Metabolic Process Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Cell Development Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Peptide Hormone Protein Kinase Binding Regulation Of Cell Activation Positive Regulation Of Developmental Process Regulation Of Biological Quality	TOR Signaling TORC1 Signaling Cellular Response To Nutrient Levels Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Translational Initiation Response To Nutrient Levels Intracellular Signal Transduction Regulation Of Translational Initiation Protein Serine Kinase Activity Insulin Receptor Signaling Pathway Protein Serine/threonine Kinase Activity Regulation Of Translation Negative Regulation Of TOR Signaling Positive Regulation Of Translational Initiation Autophagosome Assembly Autophagosome Organization Negative Regulation Of Autophagy Cellular Response To Amino Acid Starvation Protein Kinase Activity Cellular Response To Starvation Negative Regulation Of Translation Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling Autophagy Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Lipid Metabolic Process Response To Starvation Post-transcriptional Regulation Of Gene Expression Kinase Activity Positive Regulation Of Small Molecule Metabolic Process Regulation Of Autophagy Negative Regulation Of Catabolic Process Vacuole Organization Regulation Of Glycolytic Process Organelle Assembly Positive Regulation Of Glycolytic Process Cytoplasmic Translation Positive Regulation Of Intracellular Signal Transduction Regulation Of Carbohydrate Catabolic Process Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Insulin Receptor Signaling Pathway Regulation Of ATP Metabolic Process Nucleotide Binding Insulin-like Growth Factor Receptor Signaling Pathway Intracellular Signaling Cassette Regulation Of Purine Nucleotide Metabolic Process
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