RPTOR and PRKAA1

Number of citations of the paper that reports this interaction (PubMedID 18439900)
51

Data Source:
BioGRID (enzymatic study)

		RPTOR	PRKAA1
Description		regulatory associated protein of MTOR complex 1	protein kinase AMP-activated catalytic subunit alpha 1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Cytoplasmic Stress Granule Membrane Dendrite TORC1 Complex Neuronal Cell Body Serine/threonine Protein Kinase Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Cilium Apical Plasma Membrane Nuclear Speck Axon Dendrite Nucleotide-activated Protein Kinase Complex Protein-containing Complex Ciliary Basal Body Neuronal Cell Body
	Molecular Function	Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Kinase Activator Activity Protein-macromolecule Adaptor Activity Small GTPase Binding Protein-containing Complex Binding 14-3-3 Protein Binding Enzyme-substrate Adaptor Activity	Nucleotide Binding Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein-containing Complex Binding Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Histone H2BS36 Kinase Activity
	Biological Process	Autophagosome Assembly Regulation Of Cell Growth Positive Regulation Of Endothelial Cell Proliferation Cytoplasmic Translation DNA Damage Response Regulation Of Cell Size Cellular Response To Starvation Response To Xenobiotic Stimulus Regulation Of Autophagy Negative Regulation Of Autophagy Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Social Behavior TORC1 Signaling Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of Transcription By RNA Polymerase III Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Positive Regulation Of Lipid Biosynthetic Process Protein Localization To Lysosome Regulation Of Biological Quality Cellular Response To Amino Acid Stimulus Cellular Response To L-leucine Cellular Response To Glucose Stimulus Cellular Response To Hypoxia Cellular Response To Osmotic Stress Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Odontoblast Differentiation Positive Regulation Of TORC1 Signaling Positive Regulation Of Pentose-phosphate Shunt	Autophagosome Assembly Response To Hypoxia Cytoplasmic Translation Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Glucose Metabolic Process Chromatin Organization Chromatin Remodeling Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Phosphatidylethanolamine Biosynthetic Process Phosphatidylcholine Biosynthetic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Autophagy Lysosome Organization Signal Transduction Steroid Metabolic Process Cholesterol Metabolic Process Positive Regulation Of Cell Population Proliferation Lipid Biosynthetic Process Cellular Response To Starvation Response To Xenobiotic Stimulus Response To UV Cold Acclimation Response To Gamma Radiation Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Response To Activity Wnt Signaling Pathway Sterol Biosynthetic Process Fatty Acid Oxidation Response To Caffeine SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Cellular Response To Stress Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress TORC1 Signaling Cellular Response To Glucose Starvation Response To Hydrogen Peroxide Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Regulation Of Vascular Permeability Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Estrogen Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Glycolytic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Negative Regulation Of Glucosylceramide Biosynthetic Process Negative Regulation Of Insulin Receptor Signaling Pathway Rhythmic Process Positive Regulation Of Skeletal Muscle Tissue Development Protein Stabilization Negative Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Negative Regulation Of Lipid Catabolic Process Fatty Acid Homeostasis Regulation Of Vesicle-mediated Transport Protein Localization To Lysosome Motor Behavior CAMKK-AMPK Signaling Cascade Regulation Of Stress Granule Assembly Protein-containing Complex Assembly Neuron Cellular Homeostasis Cellular Response To Hydrogen Peroxide Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Calcium Ion Cellular Response To Glucose Stimulus Cellular Response To Ethanol Cellular Response To Prostaglandin E Stimulus Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Protein K6-linked Ubiquitination Positive Regulation Of Release Of Cytochrome C From Mitochondria Energy Homeostasis Hepatocyte Apoptotic Process Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Mitochondrial Transcription Positive Regulation Of Protein Localization Negative Regulation Of Hepatocyte Apoptotic Process Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Adipose Tissue Development Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Protein Localization To Lipid Droplet
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1	Macroautophagy Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs			Adenosine phosphate Adenosine phosphate ATP Phenformin Acetylsalicylic acid Fostamatinib Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Body mass index ( 25673413 28892062) Body size at age 10 ( 32376654) Hypertension ( 30487518) Mean arterial pressure ( 30487518) NASH resolution in nonalcoholic steatohepatitis ( 31832568) Nicotine dependence symptom count ( 25555482) Obesity ( 23563607) Pulse pressure ( 29403010 30487518) Systolic blood pressure ( 30487518)	Cardia gastric cancer ( 26129866) Gastric cancer ( 22037551 26098866 26129866 31383772) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Non-cardia gastric cancer ( 26129866 26701879)
Interacting Genes		35 interacting genes: BAHCC1 CBX8 CCDC40 CILK1 DCXR DUXAP9 EIF4EBP1 EIF4EBP2 GTF3C5 IRS1 IRS2 LINC00839 MAPK1 MAPK3 MARK4 MLST8 MTOR NLK NRBF2 OGT PLD2 PPDPF PRKAA1 PRKAA2 RAP1B RHEB RNF213 RPS6KA1 RPS6KA3 RPS6KB1 RRAGB TNRC6C USP36 WDR45B WIPI2	72 interacting genes: ABI2 ACACA AGAP2 ATM BHLHE40 CAB39 CAMKK1 CDX4 CFTR CHEK1 CRTC2 CTBP1 DVL2 EEF2K EPM2A FANCA FNIP1 GATA1 GOLGA2 GRIK2 HDAC5 HMBOX1 HOMEZ IKZF3 INO80E KIF16B KRT40 L3MBTL3 MAGEA3 MAGEA6 MDM4 MORC4 MTOR MTUS2 PASK PFKFB2 PHC2 PNMA5 PPM1A PPM1E PPM1F PPP2CA PRKAB1 PRKAB2 PRKAG1 PRKAG3 PSMD11 RACK1 RAD54B RAF1 RBPMS RFX6 RIMBP3 ROPN1 RPTOR SLC31A1 SRPK2 SSX2IP THAP1 TLE5 TOMM34 TRIM27 TRIM28 TRIP6 TSC2 TSC22D4 TXNIP UBXN11 ULK1 VPS37B VPS52 ZBED1
Entrez ID		57521	5562
HPRD ID		06184	04115
Ensembl ID		ENSG00000141564	ENSG00000132356
Uniprot IDs		Q8N122	Q13131
PDB IDs		5H64 6BCU 6BCX 6SB0 6SB2 6U62 7OWG 7PEA 7PEB 7PEC 7UX2 7UXC 7UXH 8ERA 8RCH 8RCK 8RCN 9F42 9F43 9F44 9F45	4RED 4RER 4REW 5EZV 6C9F 6C9G 6C9H 6C9J 7JHG 7JHH 7JIJ 7M74
Enriched GO Terms of Interacting Partners?		TOR Signaling TORC1 Signaling Cellular Response To Nutrient Levels Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Translational Initiation Response To Nutrient Levels Intracellular Signal Transduction Regulation Of Translational Initiation Protein Serine Kinase Activity Insulin Receptor Signaling Pathway Protein Serine/threonine Kinase Activity Regulation Of Translation Negative Regulation Of TOR Signaling Positive Regulation Of Translational Initiation Autophagosome Assembly Autophagosome Organization Negative Regulation Of Autophagy Cellular Response To Amino Acid Starvation Protein Kinase Activity Cellular Response To Starvation Negative Regulation Of Translation Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling Autophagy Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Lipid Metabolic Process Response To Starvation Post-transcriptional Regulation Of Gene Expression Kinase Activity Positive Regulation Of Small Molecule Metabolic Process Regulation Of Autophagy Negative Regulation Of Catabolic Process Vacuole Organization Regulation Of Glycolytic Process Organelle Assembly Positive Regulation Of Glycolytic Process Cytoplasmic Translation Positive Regulation Of Intracellular Signal Transduction Regulation Of Carbohydrate Catabolic Process Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Insulin Receptor Signaling Pathway Regulation Of ATP Metabolic Process Nucleotide Binding Insulin-like Growth Factor Receptor Signaling Pathway Intracellular Signaling Cassette Regulation Of Purine Nucleotide Metabolic Process	Nucleus Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Phosphorylation Regulation Of Macromolecule Metabolic Process Nucleotide-activated Protein Kinase Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Autophagy Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Nucleoplasm Cytosol Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Cellular Response To Nutrient Levels AMP-activated Protein Kinase Activity Protein Phosphorylation Cytoplasm Regulation Of Glycolytic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Autophagy Negative Regulation Of Catabolic Process Response To Starvation Protein Binding Protein Modification Process Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Biosynthetic Process Regulation Of ATP Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Protein Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of Cell Cycle Cation Binding Response To Nutrient Levels Protein Serine/threonine Phosphatase Activity Negative Regulation Of TOR Signaling Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process
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