PIGA and PIGY

Number of citations of the paper that reports this interaction (PubMedID 16162815)
37

Data Source:
HPRD (in vivo)

		PIGA	PIGY
Description		phosphatidylinositol glycan anchor biosynthesis class A	phosphatidylinositol glycan anchor biosynthesis class Y
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Protein Binding UDP-glycosyltransferase Activity Transferase Activity Glycosyltransferase Activity Phosphatidylinositol N-acetylglucosaminyltransferase Activity	Protein Binding Phosphatidylinositol N-acetylglucosaminyltransferase Activity
	Biological Process	GPI Anchor Biosynthetic Process Lipid Metabolic Process Cellular Response To Leukemia Inhibitory Factor	GPI Anchor Biosynthetic Process
Pathways		Synthesis of glycosylphosphatidylinositol (GPI)	Synthesis of glycosylphosphatidylinositol (GPI)
Drugs
Diseases		Paroxysmal nocturnal hemoglobinuria (PNH)
GWAS			Bipolar disorder ( 22925353) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		5 interacting genes: DPM2 LRP1 PIGH PIGQ PIGY	5 interacting genes: ABCB4 ERG28 FBXO7 PIGA TMEM72
Entrez ID		5277	84992
HPRD ID		02410	17492
Ensembl ID		ENSG00000165195	ENSG00000255072
Uniprot IDs		A0A2K4ZA02 P37287	Q3MUY2
PDB IDs
Enriched GO Terms of Interacting Partners?		Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Metabolic Process Glycerophospholipid Biosynthetic Process Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process Glycerophospholipid Metabolic Process Phosphatidylinositol N-acetylglucosaminyltransferase Activity Glycerolipid Metabolic Process Phospholipid Metabolic Process Lipid Metabolic Process Carbohydrate Derivative Biosynthetic Process Lipid Biosynthetic Process Organophosphate Biosynthetic Process Carbohydrate Derivative Metabolic Process Organophosphate Metabolic Process Endoplasmic Reticulum Membrane Phosphate-containing Compound Metabolic Process Terpenoid Metabolic Process Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Endoplasmic Reticulum Isoprenoid Metabolic Process Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Lipoprotein Particle Receptor Binding Dolichol-phosphate-mannose Synthase Complex Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Dolichol Phosphate Mannose Biosynthetic Process Positive Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process In The Vacuole Amyloid-beta Clearance By Transcytosis Positive Regulation Of Amyloid-beta Clearance Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Amyloid-beta Clearance By Cellular Catabolic Process Clathrin Heavy Chain Binding Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Plasma Membrane Protein Complex Low-density Lipoprotein Particle Receptor Activity Lipoprotein Transport Astrocyte Activation Heparan Sulfate Proteoglycan Binding Apolipoprotein Binding	Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Cellular Response To Bile Acid Response To Fenofibrate Ceramide Floppase Activity Ceramide Translocation Lewy Body Core Intercellular Canaliculus Positive Regulation Of Phospholipid Translocation Bile Acid Secretion Sphingolipid Translocation Response To Bile Acid Phosphatidylcholine Floppase Activity Phosphatidylinositol N-acetylglucosaminyltransferase Activity Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Lipid Metabolic Process ATPase-coupled Intramembrane Lipid Transporter Activity Positive Regulation Of Phospholipid Transport Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
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