DYRK3 and ADAM22

Number of citations of the paper that reports this interaction (PubMedID 36585413)
42

Data Source:
BioGRID (two hybrid)

		DYRK3	ADAM22
Description		dual specificity tyrosine phosphorylation regulated kinase 3	ADAM metallopeptidase domain 22
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GO Annotations	Cellular Component	Pericentriolar Material Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Stress Granule Nuclear Speck	Plasma Membrane Membrane Axon Cell Projection Postsynaptic Density Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Metalloendopeptidase Activity Integrin Binding Protein Binding Metallopeptidase Activity Signaling Receptor Activity
	Biological Process	Protein Phosphorylation Erythrocyte Differentiation Nuclear Speck Organization Stress Granule Disassembly Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Cell Division Regulation Of Cellular Response To Stress Positive Regulation Of Cell Cycle G2/M Phase Transition Organelle Disassembly Regulation Of TORC1 Signaling	Proteolysis Cell Adhesion Negative Regulation Of Cell Adhesion Central Nervous System Development Positive Regulation Of Synaptic Transmission
Pathways			LGI-ADAM interactions
Drugs
Diseases
GWAS		Mean corpuscular volume ( 32888494)	Blood protein levels ( 30072576) Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) ( 21221126)
Interacting Genes		12 interacting genes: ACAA2 ADAM22 DNAJA2 DNAJB1 FBXO25 GORASP2 MAGI2 NEDD4L PGM1 PRNP SNAPIN ZNF350	9 interacting genes: APP DYRK1A DYRK3 EPS8 LCOR LGI1 RAC2 YWHAB YWHAZ
Entrez ID		8444	53616
HPRD ID		04607	04751
Ensembl ID		ENSG00000143479	ENSG00000008277
Uniprot IDs		O43781	H7C3I4 Q08AL8 Q9P0K1
PDB IDs		5Y86	3G5C 5Y2Z 5Y31 7CQF 8HPY 8HQ1 8HQ2 8Y6B
Enriched GO Terms of Interacting Partners?		Protein-folding Chaperone Binding	Negative Regulation Of Protein Localization To Nucleus Phosphoserine Residue Binding Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Protein Localization To Nucleus Protein Serine/threonine/tyrosine Kinase Activity Amyloid-beta Complex Regulation Of Cellular Component Organization Regulation Of Amyloid Precursor Protein Catabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Negative Regulation Of Protein Localization Negative Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Neuron Recognition Regulation Of Cell Communication Negative Regulation Of Cell Communication Regulation Of Signaling Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Histone H3T45 Kinase Activity Protein Sequestering Activity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Intracellular Signaling Cassette Protein Phosphorylation Adult Locomotory Behavior Regulation Of Supramolecular Fiber Organization Regulation Of Protein Localization Phosphorylation Actin Filament Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Synaptic Target Recognition PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Cell Recognition Regulation Of Establishment Of Protein Localization Regulation Of Signal Transduction Axon Midline Choice Point Recognition Positive Regulation Of Chemotaxis Dendrite Endosome To Plasma Membrane Transport Vesicle
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