PGF and NRP2

Number of citations of the paper that reports this interaction (PubMedID 10748121)
0

Data Source:
HPRD (in vivo)

		PGF	NRP2
Description		placental growth factor	neuropilin 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane	Semaphorin Receptor Complex Extracellular Region Plasma Membrane Membrane Axon Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	Vascular Endothelial Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity Receptor Ligand Activity	Vascular Endothelial Growth Factor Receptor Activity Protein Binding Heparin Binding Semaphorin Receptor Activity Growth Factor Binding Cytokine Binding Signaling Receptor Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Angiogenesis Response To Hypoxia Sprouting Angiogenesis Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Cell Differentiation Vascular Endothelial Growth Factor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Mast Cell Chemotaxis	Angiogenesis Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Outflow Tract Septum Morphogenesis Cell Adhesion Nervous System Development Axon Guidance Heart Development Positive Regulation Of Endothelial Cell Migration Facial Nerve Structural Organization Trigeminal Nerve Structural Organization Vestibulocochlear Nerve Structural Organization Nerve Development Branchiomotor Neuron Axon Guidance Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Cell Differentiation Trunk Neural Crest Cell Migration Ventral Trunk Neural Crest Cell Migration Vascular Endothelial Growth Factor Signaling Pathway Axon Extension Involved In Axon Guidance Negative Chemotaxis Sympathetic Ganglion Development Trigeminal Ganglion Development Semaphorin-plexin Signaling Pathway Sensory Neuron Axon Guidance Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Regulation Of Postsynapse Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Facioacoustic Ganglion Development Dorsal Root Ganglion Morphogenesis Cellular Response To Leukemia Inhibitory Factor
Pathways		VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization	Neurophilin interactions with VEGF and VEGFR NrCAM interactions
Drugs		Aflibercept	ATYR1923
Diseases
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Mood instability ( 29187730) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301)	Blood protein levels ( 30072576) Craniofacial microsomia ( 26853712) Daytime nap ( 33568662) Diisocyanate-induced asthma ( 25918132) Neuropathy x type 2 diabetes interaction ( 32541925)
Interacting Genes		4 interacting genes: FLT1 NRP1 NRP2 VEGFA	11 interacting genes: FLT1 L1CAM NRP1 PGF PLXNA1 PLXNB1 SEMA3B SEMA3C SEMA3F SEMA4F VEGFA
Entrez ID		5228	8828
HPRD ID		03076	03643
Ensembl ID		ENSG00000119630	ENSG00000118257
Uniprot IDs		G3XA84 P49763 Q53XY6 Q86TW6	O60462
PDB IDs		1FZV 1RV6	2QQJ 2QQK 2QQL 2QQO 4QDQ 4QDR 4QDS 5DN2 5DQ0 6GH8 6TDB 6TJT 7M22 7T4S 8IVW 8IVX
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Signaling Pathway Vascular Endothelial Growth Factor Receptor Activity Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus VEGF-activated Neuropilin Signaling Pathway Vestibulocochlear Nerve Structural Organization Dorsal Root Ganglion Morphogenesis Sensory Neuron Axon Guidance Facioacoustic Ganglion Development Growth Factor Binding Angiogenesis Chemotaxis Ventral Trunk Neural Crest Cell Migration Locomotion Regulation Of Epithelial Cell Proliferation Neuropilin Signaling Pathway Sympathetic Neuron Projection Guidance Trigeminal Ganglion Development Cranial Ganglion Development Trunk Neural Crest Cell Migration Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Endothelial Cell Proliferation Trigeminal Nerve Structural Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Sympathetic Neuron Projection Extension Blood Vessel Morphogenesis Branchiomotor Neuron Axon Guidance Positive Regulation Of Cell Migration Hypothalamus Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Locomotion Coronary Artery Morphogenesis Facial Nerve Structural Organization Sympathetic Ganglion Development Enzyme-linked Receptor Protein Signaling Pathway Coronary Vasculature Morphogenesis Endothelial Cell Chemotaxis Axon Extension Involved In Axon Guidance Neuron Migration Motor Neuron Migration Heparin Binding Semaphorin Receptor Activity Commissural Neuron Axon Guidance Semaphorin Receptor Complex Positive Regulation Of Angiogenesis	Semaphorin-plexin Signaling Pathway Chemotaxis Locomotion Neuron Projection Guidance Neuropilin Binding Semaphorin Receptor Binding Cell Migration Regulation Of Cell Migration Regulation Of Cell Motility Cell Motility Regulation Of Locomotion Axon Guidance Neuron Projection Development Neural Crest Cell Migration Regulation Of Axonogenesis Mesenchymal Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Vascular Endothelial Growth Factor Signaling Pathway Cell Projection Organization Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Regulation Of Axon Extension Chemorepellent Activity Cell Surface Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Sprouting Angiogenesis Plasma Membrane Bounded Cell Projection Organization Negative Chemotaxis Ameboidal-type Cell Migration Regulation Of Neurogenesis Semaphorin Receptor Activity Semaphorin Receptor Complex Regulation Of Neuron Projection Development Regulation Of Nervous System Development Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Axonogenesis Regulation Of Anatomical Structure Morphogenesis Retinal Ganglion Cell Axon Guidance VEGF-activated Neuropilin Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Developmental Growth Negative Regulation Of Axon Extension Ventral Trunk Neural Crest Cell Migration Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Positive Regulation Of Axon Extension Vascular Endothelial Growth Factor Receptor Binding Sympathetic Neuron Projection Guidance Neuropilin Signaling Pathway
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