PGF

Description		placental growth factor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane
	Molecular Function	Vascular Endothelial Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity Receptor Ligand Activity
	Biological Process	Angiogenesis Response To Hypoxia Sprouting Angiogenesis Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Cell Differentiation Vascular Endothelial Growth Factor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Mast Cell Chemotaxis
Pathways		VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization
Drugs		Aflibercept
Diseases
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Mood instability ( 29187730) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301)
Novel Interacting Genes		4 novel interacting genes: FLT1 NRP1 NRP2 VEGFA
Interacting Genes		4 interacting genes: FLT1 NRP1 NRP2 VEGFA
Entrez ID		5228
HPRD ID		03076
Ensembl ID		ENSG00000119630
Uniprot IDs		G3XA84 P49763 Q53XY6 Q86TW6
PDB IDs		1FZV 1RV6
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Signaling Pathway Vascular Endothelial Growth Factor Receptor Activity Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus VEGF-activated Neuropilin Signaling Pathway Vestibulocochlear Nerve Structural Organization Dorsal Root Ganglion Morphogenesis Sensory Neuron Axon Guidance Facioacoustic Ganglion Development Growth Factor Binding Angiogenesis Chemotaxis Ventral Trunk Neural Crest Cell Migration Locomotion Regulation Of Epithelial Cell Proliferation Neuropilin Signaling Pathway Sympathetic Neuron Projection Guidance Trigeminal Ganglion Development Cranial Ganglion Development Trunk Neural Crest Cell Migration Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Endothelial Cell Proliferation Trigeminal Nerve Structural Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Sympathetic Neuron Projection Extension Blood Vessel Morphogenesis Branchiomotor Neuron Axon Guidance Positive Regulation Of Cell Migration Hypothalamus Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Locomotion Coronary Artery Morphogenesis Facial Nerve Structural Organization Sympathetic Ganglion Development Enzyme-linked Receptor Protein Signaling Pathway Coronary Vasculature Morphogenesis Endothelial Cell Chemotaxis Axon Extension Involved In Axon Guidance Neuron Migration Motor Neuron Migration Heparin Binding Semaphorin Receptor Activity Commissural Neuron Axon Guidance Semaphorin Receptor Complex Positive Regulation Of Angiogenesis
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