PFN2 and RNF146

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PFN2	RNF146
Description		profilin 2	ring finger protein 146
Image
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding ATP Hydrolysis Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Poly-ADP-D-ribose Binding
	Biological Process	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Peptidyl-serine Phosphorylation Modulation Of Chemical Synaptic Transmission Protein Stabilization Positive Regulation Of Stress Fiber Assembly Modification Of Postsynaptic Actin Cytoskeleton Presynaptic Actin Cytoskeleton Organization Presynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Exocytosis	Ubiquitin-dependent Protein Catabolic Process Wnt Signaling Pathway Protein Ubiquitination Protein Autoubiquitination Protein K48-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Signaling by ROBO receptors RHO GTPases Activate Formins RHO GTPases Activate Formins	TCF dependent signaling in response to WNT Degradation of AXIN Ub-specific processing proteases Regulation of PTEN stability and activity
Drugs		Triglyme Pentaglyme
Diseases
GWAS		Fish- and plant-related diet ( 32066663)	Breast cancer ( 18326623) Diverticular disease ( 30177863) Food addiction ( 27106561) Intracranial volume ( 22504418) LDL cholesterol levels in HIV infection ( 33109212) Subcortical brain region volumes ( 25607358) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		34 interacting genes: ACTB ACTG1 ANTKMT BIRC2 CFAP263 DDX11 DLST DNM1 EEF1A1 ERCC6 EVL FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MSANTD3 MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPTIN5 SGTA SNTA1 SYN1 TERF1 VASP WDR33	12 interacting genes: KASH5 NDUFAF3 PFN2 TGFBR1 TNKS TRAF2 TUBGCP4 UBE2D2 UBE2G2 UBE2H XRCC1 XRCC6
Entrez ID		5217	81847
HPRD ID		01451	11511
Ensembl ID		ENSG00000070087	ENSG00000118518
Uniprot IDs		P35080	Q9NTX7
PDB IDs		1D1J	2D8T 3V3L 6CF6
Enriched GO Terms of Interacting Partners?		Profilin Binding Cytoskeleton Bleb Schaffer Collateral - CA1 Synapse Regulation Of Organelle Organization Regulation Of Synaptic Vesicle Endocytosis Regulation Of Transepithelial Transport Regulation Of Synaptic Vesicle Recycling Dense Body Regulation Of Stress Fiber Assembly Morphogenesis Of A Polarized Epithelium Response To Bleomycin Positive Regulation Of Organelle Organization Structural Constituent Of Postsynaptic Actin Cytoskeleton Identical Protein Binding Actin Binding Cell Projection Axon Regulation Of Cellular Component Organization Focal Adhesion Regulation Of Actin Filament Organization Nitric-oxide Synthase Binding Protein Homotetramerization Positive Regulation Of Cellular Component Organization Negative Regulation Of Cellular Component Organization Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Lamellipodium Regulation Of Actin Cytoskeleton Organization Protein Localization To Cell-cell Junction Calyx Of Held Actin Cytoskeleton Organization Regulation Of Vesicle-mediated Transport Postsynaptic Cytoskeleton Organization Protein Tetramerization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Positive Regulation Of Double-strand Break Repair Apical Junction Complex Actin Filament-based Process Protein Kinase Binding NuA4 Histone Acetyltransferase Complex Maintenance Of Blood-brain Barrier Regulation Of Chromosome Organization Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Basal Body Patch Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Cortical Actin Cytoskeleton Organization Negative Regulation Of Protein Binding	Protein Polyubiquitination Ubiquitin Conjugating Enzyme Activity Chromosome, Telomeric Region Ubiquitin-protein Transferase Activity Protein Ubiquitination Regulation Of Telomere Capping Spindle Assembly Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Spindle Organization Negative Regulation Of Telomere Maintenance Protein Modification Process Peptidyl-serine Phosphorylation Double-strand Break Repair Positive Regulation Of Protein Phosphorylation DNA Recombination Transferase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Stress Fiber Assembly TORC2 Complex Disassembly Oxidized DNA Binding Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Protein Modification Process Positive Regulation Of Actin Filament Bundle Assembly Membraneless Organelle Assembly Damaged DNA Binding Positive Regulation Of Phosphate Metabolic Process Macromolecule Metabolic Process Chromosome Vascular Endothelial Cell Proliferation Epicardium Morphogenesis TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Protein Autoubiquitination Negative Regulation Of Protein ADP-ribosylation Negative Regulation Of Chromosome Organization Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric Meiotic Spindle Pole Chromosome Organization ATP Binding Positive Regulation Of Protein Modification Process DNA End Binding Telomere Maintenance Regulation Of Protein Phosphorylation Ku70:Ku80 Complex Regulation Of Stress Fiber Assembly Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis
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