PFN2 and NDUFB8

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PFN2	NDUFB8
Description		profilin 2	NADH:ubiquinone oxidoreductase subunit B8
Image
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Respiratory Chain Complex I
	Molecular Function	Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding ATP Hydrolysis Activity	NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Peptidyl-serine Phosphorylation Modulation Of Chemical Synaptic Transmission Protein Stabilization Positive Regulation Of Stress Fiber Assembly Modification Of Postsynaptic Actin Cytoskeleton Presynaptic Actin Cytoskeleton Organization Presynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Exocytosis	Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport
Pathways		Signaling by ROBO receptors RHO GTPases Activate Formins RHO GTPases Activate Formins	Mitochondrial protein import Mitochondrial protein import Respiratory electron transport Complex I biogenesis
Drugs		Triglyme Pentaglyme	NADH
Diseases
GWAS		Fish- and plant-related diet ( 32066663)	Brain morphology (MOSTest) ( 32665545) Palmitoleic acid (16:1n-7) levels ( 23362303)
Interacting Genes		34 interacting genes: ACTB ACTG1 ANTKMT BIRC2 CFAP263 DDX11 DLST DNM1 EEF1A1 ERCC6 EVL FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MSANTD3 MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPTIN5 SGTA SNTA1 SYN1 TERF1 VASP WDR33	6 interacting genes: ATP6V0D2 CACNA1A EIF2B3 PFN2 PIM2 ZAP70
Entrez ID		5217	4714
HPRD ID		01451	11886
Ensembl ID		ENSG00000070087	ENSG00000166136
Uniprot IDs		P35080	O95169
PDB IDs		1D1J	5XTC 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		Profilin Binding Cytoskeleton Bleb Schaffer Collateral - CA1 Synapse Regulation Of Organelle Organization Regulation Of Synaptic Vesicle Endocytosis Regulation Of Transepithelial Transport Regulation Of Synaptic Vesicle Recycling Dense Body Regulation Of Stress Fiber Assembly Morphogenesis Of A Polarized Epithelium Response To Bleomycin Positive Regulation Of Organelle Organization Structural Constituent Of Postsynaptic Actin Cytoskeleton Identical Protein Binding Actin Binding Cell Projection Axon Regulation Of Cellular Component Organization Focal Adhesion Regulation Of Actin Filament Organization Nitric-oxide Synthase Binding Protein Homotetramerization Positive Regulation Of Cellular Component Organization Negative Regulation Of Cellular Component Organization Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Lamellipodium Regulation Of Actin Cytoskeleton Organization Protein Localization To Cell-cell Junction Calyx Of Held Actin Cytoskeleton Organization Regulation Of Vesicle-mediated Transport Postsynaptic Cytoskeleton Organization Protein Tetramerization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Positive Regulation Of Double-strand Break Repair Apical Junction Complex Actin Filament-based Process Protein Kinase Binding NuA4 Histone Acetyltransferase Complex Maintenance Of Blood-brain Barrier Regulation Of Chromosome Organization Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Basal Body Patch Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Cortical Actin Cytoskeleton Organization Negative Regulation Of Protein Binding
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